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Table 5 Change in prevalence rates of NTDs due to FA supplementation by NTD type and sex in northern China, 1993–1995 (per 1000 births)

From: Periconceptional folic acid supplementation and sex difference in prevention of neural tube defects and their subtypes in China: results from a large prospective cohort study

Change Male Female Female–Male DID Value P value
rate rate   
Open NTDs 2.6 7.5 4.9 0.000
Anencephaly 1.6 4.8 3.2 0.000
Spina bifida 1.1 2.7 1.6 0.083
Encephalocele 0.2 0.1 −0.1 0.587
Total NTDs 2.8 7.6 4.8 0.000
  1. Rate of prevalence decrease = Prevalence of group without FA supplementation – Prevalence of group with FA supplementation
  2. NTD neural tube defect, FA folic acid