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Table 5 Change in prevalence rates of NTDs due to FA supplementation by NTD type and sex in northern China, 1993–1995 (per 1000 births)

From: Periconceptional folic acid supplementation and sex difference in prevention of neural tube defects and their subtypes in China: results from a large prospective cohort study

Change

Male

Female

Female–Male DID Value

P value

rate

rate

  

Open NTDs

2.6

7.5

4.9

0.000

Anencephaly

1.6

4.8

3.2

0.000

Spina bifida

1.1

2.7

1.6

0.083

Encephalocele

0.2

0.1

−0.1

0.587

Total NTDs

2.8

7.6

4.8

0.000

  1. Rate of prevalence decrease = Prevalence of group without FA supplementation – Prevalence of group with FA supplementation
  2. NTD neural tube defect, FA folic acid