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Table 2 Prevalence of NTDs by sex and folic acid supplementation in northern China, 1993–1995 (per 1000 births)

From: Periconceptional folic acid supplementation and sex difference in prevention of neural tube defects and their subtypes in China: results from a large prospective cohort study

Folic acid N Open NTDs Anencephaly Spina Bifida Encephalocele Total NTDs
  Male Female Total Male Female Total Male Female Total Male Female Total Male Female Total
Yes* 18,201 1.2 1.2 1.2 0.1 0.2 0.2 1.1 0.9 1.0 0.2 0.1 0.2 1.4 1.3 1.3
No 12,664 3.8 8.7 6.1 1.7 5.0 3.2 2.1 3.7 2.8 0.5 0.2 0.3 4.2 8.8 6.4
Total 30,801 2.2 4.2 3.2 0.7 2.2 1.4 1.5 2.0 1.8 0.3 0.1 0.2 2.5 4.4 3.4
  1. NTD neural tube defect
  2. *Compared to group without folic acid supplementation, P < 0.001