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Table 3 Association between wGRS and dietary factors or BMI

From: Gene-diet interaction effects on BMI levels in the Singapore Chinese population

  SCHS CAD cases N = 594 SCHS CAD controls N = 1070 SP2610 N = 1145 SP21m N = 949 SCHS T2D cases N = 2004 SCHS T2D controls N = 2055 Meta-analysis of all datasets N = 7817
  Beta SE P Beta SE P Beta SE P Beta SE P Beta SE P Beta SE P Beta SE P Padjust Qp-value
BMI 0.018 0.008 0.023 0.025 0.006 < 0.001 0.019 0.006 0.001 0.019 0.006 0.002 0.010 0.004 0.023 0.018 0.004 < 0.001 0.018 0.002 1.55x1015   0.488
AHEI-2010 0.037 0.060 0.535 −0.060 0.043 0.163 − 0.016 0.048 0.736 0.114 0.051 0.025 −0.031 0.033 0.353 −0.025 0.033 0.449 −0.010 0.017 0.540 1.000 0.130
Calories −0.001 0.007 0.892 − 0.011 0.005 0.043 0.005 0.006 0.369 −0.005 0.006 0.407 −0.003 0.004 0.445 −0.001 0.004 0.763 − 0.003 0.002 0.190 1.000 0.468
%Proteina − 0.010 0.008 0.222 −0.005 0.006 0.409 0.004 0.006 0.507 0.005 0.006 0.443 0.005 0.004 0.212 0.002 0.004 0.691 0.002 0.002 0.490 1.000 0.488
%Fata −0.001 0.008 0.933 3.96 × 1004 0.006 0.945 0.010 0.006 0.080 −0.004 0.006 0.522 0.003 0.004 0.430 2.93 × 10−04 0.004 0.944 0.002 0.002 0.383 1.000 0.646
%SFAa − 0.001 0.008 0.899 0.0028 0.006 0.717 0.002 0.006 0.697 − 0.003 0.006 0.566 0.001 0.004 0.863 0.002 0.004 0.620 0.001 0.002 0.700 1.000 0.980
%MFAa 0.002 0.008 0.826 −0.001 0.006 0.810 0.010 0.006 0.083 −0.007 0.006 0.235 4.78 × 10−04 0.004 0.913 −0.001 0.004 0.727 1.95E-04 0.002 0.929 1.000 0.460
%PFAa − 0.002 0.008 0.823 −0.004 0.006 0.524 0.005 0.006 0.384 0.004 0.006 0.523 0.006 0.004 0.171 −0.001 0.004 0.812 0.002 0.002 0.420 1.000 0.715
%Carbohydratea 0.004 0.008 0.605 0.002 0.006 0.757 −0.010 0.006 0.085 0.002 0.006 0.764 −0.002 0.004 0.622 −0.002 0.004 0.704 −0.002 0.002 0.466 1.000 0.656
%Starcha 0.001 0.008 0.862 0.008 0.006 0.182 −0.003 0.006 0.640 −3.90 × 10− 04 0.006 0.951 −0.001 0.004 0.768 −0.004 0.004 0.402 −4.70 × 10− 04 0.002 0.829 1.000 0.734
Fiber 0.004 0.008 0.592 −0.006 0.006 0.292 −0.001 0.006 0.848 0.006 0.006 0.362 −0.004 0.004 0.349 0.001 0.004 0.892 −0.001 0.002 0.692 1.000 0.698
Cholesterol −0.013 0.008 0.092 0.003 0.006 0.624 0.006 0.006 0.334 −0.005 0.006 0.443 0.01 0.004 0.030 0.001 0.004 0.733 0.002 0.002 0.287 1.000 0.141
  1. Q p-value Cochran’s Q heterogeneity measure, SFA Saturated Fatty Acids, PUFA Polyunsaturated Fatty Acids, MUFA Monounsaturated Fatty Acids, AHEI Alternative Healthy Eating Index, SCHS Singapore Chinese Health Study, SP2 Singapore Prospective Study Program, T2D Type II diabetes
  2. Results are from meta-analysis of SCHS MI cases (N = 594) and control datasets (N = 1070), SP2 610 (N = 1145) and 1 M datasets (N = 949), SCHS Type 2 diabetes cases (N = 2004) and control datasets (N = 2055)
  3. Age gender and total calories intake were included in the linear regression model as covariates, except for BMI, AHEI-2010 and calories
  4. aRepresented as a % of Total Energy