Gene-diet interaction effects on BMI levels in the Singapore Chinese population

Chang, Xuling; Dorajoo, Rajkumar; Sun, Ye; Han, Yi; Wang, Ling; Khor, Chiea-Chuen; Sim, Xueling; Tai, E-Shyong; Liu, Jianjun; Yuan, Jian-Min; Koh, Woon-Puay; van Dam, Rob M.; Friedlander, Yechiel; Heng, Chew-Kiat

doi:10.1186/s12937-018-0340-3

Nutrition Journal

Table 2 Association between dietary factors and BMI level

From: Gene-diet interaction effects on BMI levels in the Singapore Chinese population

	SCHS CAD cases N = 594			SCHS CAD controls N = 1070			SP2610 N = 1145			SP21m N = 949			SCHS T2D cases N = 2004			SCHS T2D controls N = 2055			Meta-analysis of all datasets N = 7817
	Beta	SE	P	Beta	SE	P	Beta	SE	P	Beta	SE	P	Beta	SE	P	Beta	SE	P	Beta	SE	P	P_adjust	Q_p-value
AHEI-2010	−0.002	0.005	0.650	0.002	0.004	0.666	−0.008	0.004	0.032	0.001	0.004	0.730	−0.007	0.003	0.021	−0.003	0.003	0.318	−0.003	0.001	0.019	0.209	0.315
Calories	0.142	0.045	0.002	0.083	0.033	0.012	−0.002	0.030	0.952	0.026	0.033	0.437	−0.015	0.024	0.542	0.017	0.024	0.489	0.025	0.012	0.037	0.407	0.019
%oProtein^a	0.049	0.041	0.234	0.031	0.031	0.325	0.033	0.029	0.264	0.048	0.033	0.147	0.009	0.023	0.693	0.019	0.023	0.402	0.026	0.012	0.023	0.253	0.918
%Fat^a	− 0.008	0.042	0.848	0.084	0.032	0.008	0.009	0.033	0.773	0.08	0.036	0.028	−0.009	0.024	0.711	0.021	0.023	0.363	0.025	0.012	0.039	0.429	0.123
%SFA^a	− 0.001	0.041	0.985	0.075	0.031	0.017	−0.004	0.032	0.904	0.042	0.037	0.248	0.001	0.023	0.971	0.018	0.023	0.426	0.020	0.012	0.096	1.000	0.424
%MFA^a	0.002	0.042	0.967	0.044	0.032	0.162	0.035	0.031	0.258	0.086	0.035	0.013	−0.002	0.023	0.928	0.005	0.023	0.811	0.022	0.012	0.058	0.638	0.310
%PFA^a	− 0.049	0.041	0.232	0.054	0.031	0.080	−0.011	0.030	0.721	0.079	0.033	0.017	−0.017	0.023	0.468	0.016	0.023	0.475	0.012	0.012	0.313	1.000	0.065
%Carbohydrate^a	0.005	0.042	0.904	− 0.065	0.032	0.039	−0.010	0.032	0.762	−0.063	0.035	0.071	−0.003	0.023	0.905	−0.020	0.023	0.377	−0.023	0.012	0.047	0.517	0.480
%Starch^a	− 0.012	0.041	0.777	−0.077	0.031	0.015	−0.012	0.030	0.565	−0.100	0.033	0.003	−0.012	0.023	0.612	−0.003	0.023	0.888	−0.030	0.011	0.010	0.110	0.108
Fiber	0.029	0.041	0.484	0.023	0.031	0.445	−0.011	0.030	0.716	0.018	0.033	0.593	−0.039	0.023	0.089	−0.022	0.023	0.347	−0.009	0.012	0.421	1.000	0.463
Cholesterol	0.054	0.041	0.192	0.020	0.031	0.528	0.062	0.030	0.035	0.049	0.033	0.136	0.010	0.023	0.675	−0.005	0.022	0.823	0.023	0.011	0.042	0.462	0.433

Q_p-value Cochran’s Q heterogeneity measure, SFA Saturated Fatty Acids, PUFA Polyunsaturated Fatty Acids, MUFA Monounsaturated Fatty Acids, AHEI Alternative Healthy Eating Index, SCHS Singapore Chinese Health Study, SP2 Singapore Prospective Study Program, T2D Type II diabetes
Results are from meta-analysis of SCHS MI cases (N = 594) and control datasets (N = 1070), SP2 610 (N = 1145) and 1 M datasets (N = 949), SCHS Type 2 diabetes cases (N = 2004) and control datasets (N = 2055)
Age gender and total calories intake were included in the linear regression model as covariates, except for BMI, AHEI-2010 and calories
^aRepresented as a % of Total Energy

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