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Table 6 Change from baseline in main laboratory safety parameters, mean values

From: The effect of an apple polyphenol extract rich in epicatechin and flavan-3-ol oligomers on brachial artery flow-mediated vasodilatory function in volunteers with elevated blood pressure

   Apple extract treatment Placebo treatment
Variable Screening (SD) Change Mean (SD) Change Mean (SD)
Haemoglobin (g/l) 143.1 (11.5) 1.5 144.7 (1.5) 1.4 144.5 (1.4)
Haematocrit 0.425 (0.030) 0.001 0.426 (0.029) 0.003 0.427 (0.030)
Retikulocytes (E9/l) 1.24 (0.34) 0.06 1.31 (0.45) 0.02 1.26 (0.42)
Mean corpuscular volyme (fl) 88.8 (4.3) 0.1 88.9 (4.3) 0.2 89.0 (4.4)
Mean corpuscular haemoglobin (pg) 30.0 (1.8) 0.3 30.4 (2.0) 0.1 30.1 (1.9)
Leucocytes (E9/l) 4.92 (1.27) −0.24 4.64 (1.13) −0.11 4.77 (1.06)
Plasma albumin (g/l) 39.7 (2.5) −0.8 38.9 (2.0) −1.0 38.8 (2.1)
Plasma bilirubin (μmol/l) 11.6 (6.4) −0.4 11.4 (6.8) −0.8 11.1 (6.0)
Plasma alanine aminotransferase (U/l) 25.0 (14.8) 1.5 25.7 (13.9) 2.3 27.1 (14.4)
Plasma aspartate aminotransferase (U/l) 26.6 (8.4) −1.5 24.8 (6.4) −0.1 26.6 (10.4)
Plasma creatinine (μmol/l) 78.8 (12.7) 0.9 79.7 (12.6) 0.1 79.1 (12.5)
Plasma glutamyl transferase (U/l) 27.6 (31.3) 2.6 27.2 (33.9) 5.2 32.7 (60.9)
Plasma sodium (mmol/l) 141.3 (1.6) −0.2 141.1 (1.7) −0.3 141.0 (1.6)
Plasma potassium (mmol/l) 4.00 (0.31) 0.07 4.07 (0.26) 0.05 4.04 (0.27)
Fasting plasma calcium (mmol/l) 2.31 (0.08) 0.00 2.31 (0.08) 0.00 2.30 (0.08)
Fasting plasma urea (mmol/l) 5.18 (1.18) −0.13 5.03 (1.04) 0.06 5.24 (1.21)
Plasma uric acid (μmol/l) 301.2 (72.4) −1.5 298.1 (71.3) −9.1 291.3 (69.3)
Fasting plasma total cholesterol (mmol/l) 5.65 (0.91) −0.06 5.55 (1.02) −0.09 5.56 (0.91)
Fasting plasma HDL-cholesterol (mmol/l) 1.88 (0.52) −0.10 1.76 (0.49) −0.09 1.78 (0.48)
Fasting plasma LDL-cholesterol (mmol/l) 3.27 (0.91) 0.01 3.26 (0.91) 0.02 3.29 (0.78)
Fasting plasma triglycerides (mmol/l) 1.10 (0.56) 0.04 1.14 (0.72) −0.03 1.07 (0.52)
Fasting plasma glucose (mmol/l) 5.42 (0.46) 0.11 5.52 (0.48) 0.11 5.52 (0.49)
Plasma C-reactive protein (mg/l) 2.43 (1.57) −0.53 1.86 (1.23) 1.71 3.75 (5.24)