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Table 3 Acute change from baseline in blood pressure and biomarkers

From: The effect of an apple polyphenol extract rich in epicatechin and flavan-3-ol oligomers on brachial artery flow-mediated vasodilatory function in volunteers with elevated blood pressure

  Apple extract treatment Placebo treatment
Variable Change Mean (SD), pre Mean (SD), post Change Mean (SD), pre Mean (SD), post
Systolic blood pressure, mm Hga −0.6 145.4 (13.2) 145.3 (15.5) −1.6 148.2 (15.1) 146.7 (14.5)
Diastolic blood pressure, mm Hga −0.6 90.3 (7.1) 89.7 (8.0) 0.3 90.3 (7.0) 90.8 (7.1)
s-ICAM-1, pg/mlb −8658 267,737 (52847) 259,086 (50958) −5339 264,810 (58029) 259,375 (54260)
sVCAM-1, pg/mlb −0.10 (log) 1,555,001 (520492) 1,415,276 (561821) −0.07 (log) 1,494,420 (500826) 1,384,356 (422927)
PAI-1, pg/mlb 0.07 (log) 55,433 (28812) 61,956 (39638) 0.09 (log) 53,976 (27527) 58,703 (29755)
C-reactive protein, pg/mlb −0.10 (log) 2,791,200 (9722821) 1,230,700 (1189128) 0.02 (log) 1,396,497 (2464468) 1,530,123 (2079646)
ADMA, μmol/lb 0.005 0.776 (0.175) 0.790 (0.144) −0.012 0.791 (0.155) 0.780 (0.154)
vWf, ng/mlb 0.009 (log) 64,201 (40893) 71,662 (71789) 0.013 (log) 58,823 (40455) 65,056 (55217)
sE-selectin, pg/mlb 0.09 (log) 689.2 (315.4) 751.8 (295.6) 0.13 (log) 649.9 (279.8) 741.3 (301.3)
  1. aChange from baseline at end-of-treatment period (based on ANCOVA-model)
  2. bChange in pre-dose measurements between end and start of the treatment period (based on ANCOVA-model)