Effects of cow’s milk beta-casein variants on symptoms of milk intolerance in Chinese adults: a multicentre, randomised controlled study

Table 3 Gastrointestinal symptom scores (all study sites combined)

Variable	Time	Visit 1 (baseline)				Visit 2				GEE analysis
		A1 (n=300)^a		A2 (n=300)^a		A1 (n=300)^a		A2 (n=300)^a		Product (A2 vs. A1)
		Median	Range	Median	Range	Median	Range	Median	Range	Estimate	SE	P
Borborygmus	1 h	3	0–6	2	0–6	3	0–6	2	0–6	1.327	0.097	<0.0001
	3 h	3	0–6	2	0–6	3	0–6	2	0–5	1.912	0.103	<0.0001
	12 h	0	0–2	0	0–2	0	0–2	0	0–2	0.134	0.180	0.458
Flatulence	1 h	2	0–6	2	0–5	3	0–6	1	0–5	1.516	0.098	<0.0001
	3 h	3	0–6	2	0–5	3	0–6	2	0–4	1.869	0.101	<0.0001
	12 h	0	0–3	0	0–3	0	0–3	0	0–2	0.245	0.130	0.059
Bloating	1 h	2	0–6	1	0–6	3	0–6	1	0–5	1.474	0.098	<0.0001
	3 h	3	0–6	2	0–5	3	1–6	2	0–4	1.922	0.096	<0.0001
	12 h	2	0–5	1	0–4	2	0–4	1	0–3	0.883	0.126	<0.0001
Abdominal Pain	1 h	0	0–5	0	0–5	1	0–5	0	0–3	0.714	0.082	<0.0001
	3 h	2	0–5	1	0–4	2	0–6	0	0–3	1.903	0.101	<0.0001
	12 h	2	0–4	1	0–3	2	0–5	1	0–3	1.887	0.124	<0.0001
Stool Frequency	1 h	0	0–5	0	0–4	0	0–5	0	0–3	0.749	0.088	<0.0001
	3 h	2	0–5	0	0–3	2	0–5	0	0–3	2.276	0.110	<0.0001
	12 h	1	0–2	0	0–2	1	0–3	0	0–2	1.778	0.156	<0.0001
Stool Consistency	1 h	0	0–5	0	0–4	0	0–5	0	0–2	0.799	0.092	<0.0001
	3 h	2	0–5	0	0–4	2	0–5	0	0–2	2.375	0.115	<0.0001
	12 h	1	0–3	0	0–2	1	0–3	0	0–2	2.051	0.149	<0.0001

A1 conventional milk containing A1 and A2 β-casein, A2 milk containing A2 β-casein, GEE generalized estimating equation, SE standard error
^an=400 at 12 h (the VAS was not assessed at 12 h in Shanghai)

ISSN: 1475-2891