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Table 3 Gastrointestinal symptom scores (all study sites combined)

From: Effects of cow’s milk beta-casein variants on symptoms of milk intolerance in Chinese adults: a multicentre, randomised controlled study

Variable Time Visit 1 (baseline) Visit 2 GEE analysis
   A1 (n=300)a A2 (n=300)a A1 (n=300)a A2 (n=300)a Product (A2 vs. A1)
   Median Range Median Range Median Range Median Range Estimate SE P
Borborygmus 1 h 3 0–6 2 0–6 3 0–6 2 0–6 1.327 0.097 <0.0001
3 h 3 0–6 2 0–6 3 0–6 2 0–5 1.912 0.103 <0.0001
12 h 0 0–2 0 0–2 0 0–2 0 0–2 0.134 0.180 0.458
Flatulence 1 h 2 0–6 2 0–5 3 0–6 1 0–5 1.516 0.098 <0.0001
3 h 3 0–6 2 0–5 3 0–6 2 0–4 1.869 0.101 <0.0001
12 h 0 0–3 0 0–3 0 0–3 0 0–2 0.245 0.130 0.059
Bloating 1 h 2 0–6 1 0–6 3 0–6 1 0–5 1.474 0.098 <0.0001
3 h 3 0–6 2 0–5 3 1–6 2 0–4 1.922 0.096 <0.0001
12 h 2 0–5 1 0–4 2 0–4 1 0–3 0.883 0.126 <0.0001
Abdominal Pain 1 h 0 0–5 0 0–5 1 0–5 0 0–3 0.714 0.082 <0.0001
3 h 2 0–5 1 0–4 2 0–6 0 0–3 1.903 0.101 <0.0001
12 h 2 0–4 1 0–3 2 0–5 1 0–3 1.887 0.124 <0.0001
Stool Frequency 1 h 0 0–5 0 0–4 0 0–5 0 0–3 0.749 0.088 <0.0001
3 h 2 0–5 0 0–3 2 0–5 0 0–3 2.276 0.110 <0.0001
12 h 1 0–2 0 0–2 1 0–3 0 0–2 1.778 0.156 <0.0001
Stool Consistency 1 h 0 0–5 0 0–4 0 0–5 0 0–2 0.799 0.092 <0.0001
3 h 2 0–5 0 0–4 2 0–5 0 0–2 2.375 0.115 <0.0001
12 h 1 0–3 0 0–2 1 0–3 0 0–2 2.051 0.149 <0.0001
  1. A1 conventional milk containing A1 and A2 β-casein, A2 milk containing A2 β-casein, GEE generalized estimating equation, SE standard error
  2. an=400 at 12 h (the VAS was not assessed at 12 h in Shanghai)