Table 3 Caffeine intake and sperm variables
From: Coffee and caffeine intake and male infertility: a systematic review
Author | Number | Volume (mL) | Count (millions) | Concentration (millions/mL) | Motility (% motile forms) | Morphology (%) |
|---|---|---|---|---|---|---|
Jensen, 2010 [38] | Â | Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR)b |
Daily caffeine consumption (mg)a | ||||||
 0-100 | 1164 | 3.2 (2.3-4.3) | 146 (65-257) | 46 (22-80) | 66 (57-74) | 6.5 (3.3-8.5) |
 101-200 | 521 | 3.2 (2.4-4.1) | 133 (62-242) | 42 (20-78) | 67 (58-74) | 7.0 (4.3-9.5) |
 201-800 | 657 | 3.2 (2.4-4.1) | 149 (70-260) | 47 (23-84) | 68 (57-74) | 6.5 (3.5-9.5) |
 >800 | 63 | 3.0 (2.1-4.1) | 133 (68-192) | 41 (26-64) | 66 (57-74) | 5.5 (3.3-9.3) |
Marshburn, 1989 [22] | Â | Mean (SE) | Â | Mean (SE) | Mean (SE) | Mean (SE)c |
Coffee cups per day | ||||||
 0 | 166 | 3.0 (0.1) |  | 76.7 (3.7) | 59.0 (1.5) | 28.0 (0.8) |
 1-3 | 198 | 3.1 (0.1) |  | 89.1 (3.8) | 62.0 (1.2) | 28.0 (0.7) |
 ≥4 | 82 | 2.7 (0.8) |  | 81.4 (5.8) | 57.0 (2.5) | 31.0 (1.4) |
Oldereid, 1992 [23] | Â | Â | Â | Mean (SE) | Mean (SE)d | Mean (SE) c |
Coffee cups per day | ||||||
 0 | 45 |  |  | 69.5 (9.6) | 20.1 (2.1) | 58.5 (3.0) |
 1-5 | 133 |  |  | 87.8 (7.1) | 22.7 (1.4) | 54.2 (1.8) |
 ≥6 | 60 |  |  | 82.1 (9.9) | 22.1 (2.1) | 56.8 (2.7) |
Ramlau-Hansen, 2008 [37] | Â | Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) b |
Daily caffeine consumption (mg)a | ||||||
 0-25 | 139 | 2.8 (2.3-3.8) | 118 (50-206) | 34 (18-78) | 69 (60-76) | 5.5 (3.0-8.5) |
 50-125 | 143 | 3.3 (2.1-4.1) | 113 (39.288) | 44 (22-90) | 69 (63-77) | 5.0 (3.0-8.0) |
 175-1075 | 62 | 2.5 (2.2-3.7) | 145 (74-351) | 44 (21-96) | 71 (60-77) | 6.8 (4.0-10.0) |
Sobreiro, 2005 [33] | Â | Mean (SE) | Â | Mean (SE) | Mean (SE) | Mean (SE) b |
Coffee cups per day | ||||||
 0 | Nd | 2.7 (1.5) |  | 110.8 (79.7) | 57.1 (16.2) | 17.3 (8.2) |
 1-3 | Nd | 2.6 (1.4) |  | 113.6 (82.0) | 60.7 (14.6) | 17.5 (10.0) |
 4-6 | Nd | 2.7 (1.3) |  | 111.0 (94.8) | 61.2 (15.5) | 17.9 (8.3) |
 ≥6 | Nd | 2.7 (1.7) |  | 127.2 (82.3) | 62.4 (16.0) | 18.0 (9.2) |
Wogatzky, 2012 [39] | Â | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD)e | Â |
Coffee cups per day | ||||||
 <3 | 1479 | 2.7 (1.5) | 58.0 (91.2) | 23.1 (28.9) | 4.9 (7.9) |  |
 ≥3 | 204 | 2.6 (1.5) | 63.5 (66.9) | 25.8 (31.5) | 4.3 (8.1) |  |
Yang, 2015 [41] | Â | Median (5th and 95th percentile) | Median (5th and 95th percentile) | Median (5th and 95th percentile) | Median (5th and 95th percentile) | Median (5th and 95th percentile)b |
Coffee cups per day | ||||||
 0 | 605 | 3.4 (1.6-6.8) | 187 (37-626) | 54 (13-200) | 55 (29-81) | 8.3 (4.0-13.9) |
 1-2 | 154 | 3.1 (1.4-5.9) | 170 (39-628) | 55 (14-183) | 59 (28-85) | 8.7 (4.5-14.8) |
 ≥3 | 35 | 3.6 (1.5-7.4) | 190 (49.781) | 52 (21-226) | 60 (27-92) | 7.7 (3.9-13.0) |
Cola | ||||||
 Jensen, 2010 [38] Weekly cola consumption (0.5 L bottles) |  | Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR)b |
  0 | 379 | 3.3 (2.4-4.5) | 171 (75-295) | 50 (25-89) | 66 (57-73) | 8.0 (5.0-10.5) |
  1-7 | 1759 | 3.2 (2.3-4.2) | 143 (65-254) | 45 (22-80) | 67 (55-74) | 6.0 (3.5-9.5) |
  -14 | 262 | 3.1 (2.4-4.1) | 138 (71-241) | 47 (23-76) | 69 (58-76) | 6.0 (3.5-9.0) |
  >14 | 93 | 3.0 (2.2-4.0) | 102 (42-197) | 35 (17-66) | 66 (58-73) | 7.0 (5.0-10.0) |
 Yang, 2015 [41] Weekly cola consumption (0.55 L bottles) |  | Median (5th and 95th percentile) | Median (5th and 95th percentile) | Median (5th and 95th percentile) | Median (5th and 95th percentile) | Median (5th and 95th percentile)b |
  0 | 273 | 3.6 (1.7-6.6) | 209 (40-761) | 57 (15-211) | 54 (28-80) | 8.5 (4.4-13.5) |
  <3 | 404 | 3.4 (1.5-6.9) | 175 (37-593) | 52 (14-184) | 57 (30-84) | 8.4 (3.9-15.0) |
  ≥3 | 117 | 3.1 (1.4-5.9) | 154 (35-505) | 56 (11-158) | 71 (28-91) | 7.9 (4.3-13.9) |