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Table 3 Caffeine intake and sperm variables

From: Coffee and caffeine intake and male infertility: a systematic review

Author Number Volume (mL) Count (millions) Concentration (millions/mL) Motility (% motile forms) Morphology (%)
Jensen, 2010 [38]   Median (IQR) Median (IQR) Median (IQR) Median (IQR) Median (IQR)b
Daily caffeine consumption (mg)a
 0-100 1164 3.2 (2.3-4.3) 146 (65-257) 46 (22-80) 66 (57-74) 6.5 (3.3-8.5)
 101-200 521 3.2 (2.4-4.1) 133 (62-242) 42 (20-78) 67 (58-74) 7.0 (4.3-9.5)
 201-800 657 3.2 (2.4-4.1) 149 (70-260) 47 (23-84) 68 (57-74) 6.5 (3.5-9.5)
 >800 63 3.0 (2.1-4.1) 133 (68-192) 41 (26-64) 66 (57-74) 5.5 (3.3-9.3)
Marshburn, 1989 [22]   Mean (SE)   Mean (SE) Mean (SE) Mean (SE)c
Coffee cups per day
 0 166 3.0 (0.1)   76.7 (3.7) 59.0 (1.5) 28.0 (0.8)
 1-3 198 3.1 (0.1)   89.1 (3.8) 62.0 (1.2) 28.0 (0.7)
 ≥4 82 2.7 (0.8)   81.4 (5.8) 57.0 (2.5) 31.0 (1.4)
Oldereid, 1992 [23]     Mean (SE) Mean (SE)d Mean (SE) c
Coffee cups per day
 0 45    69.5 (9.6) 20.1 (2.1) 58.5 (3.0)
 1-5 133    87.8 (7.1) 22.7 (1.4) 54.2 (1.8)
 ≥6 60    82.1 (9.9) 22.1 (2.1) 56.8 (2.7)
Ramlau-Hansen, 2008 [37]   Median (IQR) Median (IQR) Median (IQR) Median (IQR) Median (IQR) b
Daily caffeine consumption (mg)a
 0-25 139 2.8 (2.3-3.8) 118 (50-206) 34 (18-78) 69 (60-76) 5.5 (3.0-8.5)
 50-125 143 3.3 (2.1-4.1) 113 (39.288) 44 (22-90) 69 (63-77) 5.0 (3.0-8.0)
 175-1075 62 2.5 (2.2-3.7) 145 (74-351) 44 (21-96) 71 (60-77) 6.8 (4.0-10.0)
Sobreiro, 2005 [33]   Mean (SE)   Mean (SE) Mean (SE) Mean (SE) b
Coffee cups per day
 0 Nd 2.7 (1.5)   110.8 (79.7) 57.1 (16.2) 17.3 (8.2)
 1-3 Nd 2.6 (1.4)   113.6 (82.0) 60.7 (14.6) 17.5 (10.0)
 4-6 Nd 2.7 (1.3)   111.0 (94.8) 61.2 (15.5) 17.9 (8.3)
 ≥6 Nd 2.7 (1.7)   127.2 (82.3) 62.4 (16.0) 18.0 (9.2)
Wogatzky, 2012 [39]   Mean (SD) Mean (SD) Mean (SD) Mean (SD)e  
Coffee cups per day
 <3 1479 2.7 (1.5) 58.0 (91.2) 23.1 (28.9) 4.9 (7.9)  
 ≥3 204 2.6 (1.5) 63.5 (66.9) 25.8 (31.5) 4.3 (8.1)  
Yang, 2015 [41]   Median (5th and 95th percentile) Median (5th and 95th percentile) Median (5th and 95th percentile) Median (5th and 95th percentile) Median (5th and 95th percentile)b
Coffee cups per day
 0 605 3.4 (1.6-6.8) 187 (37-626) 54 (13-200) 55 (29-81) 8.3 (4.0-13.9)
 1-2 154 3.1 (1.4-5.9) 170 (39-628) 55 (14-183) 59 (28-85) 8.7 (4.5-14.8)
 ≥3 35 3.6 (1.5-7.4) 190 (49.781) 52 (21-226) 60 (27-92) 7.7 (3.9-13.0)
Cola
 Jensen, 2010 [38] Weekly cola consumption (0.5 L bottles)   Median (IQR) Median (IQR) Median (IQR) Median (IQR) Median (IQR)b
  0 379 3.3 (2.4-4.5) 171 (75-295) 50 (25-89) 66 (57-73) 8.0 (5.0-10.5)
  1-7 1759 3.2 (2.3-4.2) 143 (65-254) 45 (22-80) 67 (55-74) 6.0 (3.5-9.5)
  -14 262 3.1 (2.4-4.1) 138 (71-241) 47 (23-76) 69 (58-76) 6.0 (3.5-9.0)
  >14 93 3.0 (2.2-4.0) 102 (42-197) 35 (17-66) 66 (58-73) 7.0 (5.0-10.0)
 Yang, 2015 [41] Weekly cola consumption (0.55 L bottles)   Median (5th and 95th percentile) Median (5th and 95th percentile) Median (5th and 95th percentile) Median (5th and 95th percentile) Median (5th and 95th percentile)b
  0 273 3.6 (1.7-6.6) 209 (40-761) 57 (15-211) 54 (28-80) 8.5 (4.4-13.5)
  <3 404 3.4 (1.5-6.9) 175 (37-593) 52 (14-184) 57 (30-84) 8.4 (3.9-15.0)
  ≥3 117 3.1 (1.4-5.9) 154 (35-505) 56 (11-158) 71 (28-91) 7.9 (4.3-13.9)
  1. IQR interquartile range, SE standard error, SD standard deviation
  2. Bold results are statistically significant
  3. a: coffe, tea, chocolates
  4. b: morphologically normal forms
  5. c: abnormal forms
  6. d: progressive motile
  7. e: grade A motility