Table 1 Main characteristics of studies on caffeine intake and male fertility
From: Coffee and caffeine intake and male infertility: a systematic review
First author, year | Country | Number | Design | Setting | Outcome measure | Age (range or mean) |
|---|---|---|---|---|---|---|
Full text | ||||||
Cole, 2006 [34] | Canada | 41 | Retrospective cohort | Obstetrics Department: planned pregnancies | Fecundability | 22-45 |
Curtis, 1997 [27] | USA | 2607 | Retrospective cohort | Couples from farms in Ontario: planned pregnancies | Fecundability | 17- > 30 |
Figà-Talamanca, 1996 [26] | Italy | 72 | Cross-sectional | Taxi drivers | Semen variables | 43.2 |
Florack, 1994 [25] | The Netherlands | 259 | Prospective cohort | Non medical hospital workers’ partners | Fecundability | Not reported |
Horak, 2003 [32] | Poland | 179 | Cross-sectional | Fertility clinic: healthy donors and men from infertile couples | Bulky DNA adducts in human sperm cells as a measure of DNA lesions | 35.2 |
Jensen, 1998 [30] | Denmark | 450 | Prospective cohort | Trade union members | Fecundability | Not reported |
Jensen, 2010 [38] | Denmark | 2554 | Cross-sectional | Young healthy men | Semen variables | 18-22 |
Jurewicz, 2014 [40] | Poland | 212 | Cross-sectional | Healty men | Sperm aneuploidy | 22-45 |
Klonoff-Cohen, 2002 [31] | USA | 221 | Prospective cohort | Fertility Clinic: infertile couples undergoing ART | Semen variables, clinical pregnancy, live birth | 38.4 |
Kobeissi, 2007 [36] | USA | 120/100 | Case-control | Fertility Clinic: infertile couples | Cases suffered from impaired sperm count and function; controls were the fertile husbands of infertile women | 38.6 cases/39.3 controls |
Marshburn, 1989 [22] | USA | 446 | Cross-sectional | Infertile men | Semen variables | Not reported |
Oldereid, 1992 [23] | Norway | 252 | Cross-sectional | Men attending a fertility laboratory | Semen variables | Not reported |
Parazzini, 1993 [24] | Italy | 97/105/120 | Case-control | Fertility clinic | Cases of dyspermia; controls: 1. normospermic men of infertile couples; 2. Fertile men of unknown semen quality | Not reported |
Radwan, 2016 [42] | Poland | 286 | Cross-sectional | Healthy men | DNA Fragmentation Index | 22.7-44.8 |
Ramlau-Hansen, 2008 [37] | Denmark | 344 | Cross-sectional | Young men, sons of mothers in Healthy Habits for Two cohort | Semen variables | 18-21 |
Robbins, 1997 [29] | USA | 45 | Cross-sectional | Young healthy men | Sperm aneuploidy | 19-35 |
Schmid, 2007 [35] | USA | 80 | Cross-sectional | Non smoker healthy men | DNA damage | 46.4 |
Sobreiro, 2005 [33] | Brazil | 500 | Cross-sectional | Candidates to vasectomy | Semen variables | 35 |
Vine, 1997 [28] | USA | 88 | Cross-sectional | Healthy males | Sperm nuclear morphometric parameters | 18-35 |
Wesselink, 2016 [43] | USA | 2135 | Prospective cohort | Couples planning a pregnancy | Fecundability | 31.8 |
Wogatzky, 2012 [39] | Austria | 1683 | Cross-sectional | Fertility clinic: infertile couples | Semen variables | 40.4 |
Yang, 2015 [41] | China | 796 | Cross-sectional | Young men | Semen variables | 20 (median) |
Published or only accessible as abstract | ||||||
Adelusi, 1998 [44] | Saudi Arabia | 68/28 | Case-control | Fertility Clinic: infertile couples | Sperm motility | Not reported |
Al-Inany, 2001 [45] | Egypt | 200 | Cross-sectional | Fertility Clinic: infertile couples | Semen variables | 23-45 |
Belloc, 2013 [46] | France | 4474 | Cross-sectional | Fertility Clinic: infertile couples | Semen variables, DNA fragmentation and chromatin decondensation | Not reported |
Karmon, 2013 [47] | USA | 166 | Cross-sectional | Fertility Clinic: infertile couples | Semen variables | 36.6 |
Karmon, 2014 [48] | USA | 105 | Prospective cohort | Fertility Clinic: infertile couples | Clinical pregnancy rate | 37 |
Pecoraro, 2015 [49] | Italy | 1134 | Cross-sectional | Fertility clinic: infertile couples | Fertility | 33.4 fertile/38.3 infertile |