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Table 2 Outcome variables before and after intervention in all patients and separately between genotypes

From: The effect of weight loss on HDL subfractions and LCAT activity in two genotypes of APOA-II -265T>C polymorphism

Subjects

Variable

Before intervention

After intervention

*P value

Mean(SD)

Mean(SD)

Total (n = 44)

 

BMI (kg/m2)

 

Normal

-

2(4.5)

 
 

Overwight

20(45.5)

28(63.5)

≤0.001a

 

obese

24(54.5)

14(32)

 
 

Waist/Hip

0.97(0.05)

0.93(0.05)

≤0.001b

 

APOA-II/APOA-I

1.46(0.26)

1.40(0.17)

0.12b

 

HDL(ng/ml)

44.90(7.99)

42.76(7.81)

≤0.001*b

 

HDL2(ng/ml)

15.38(0.29)

14.25(0.28)

0.03*b

 

HDL3(ng/ml)

29.95(0.29)

28.75(0.28)

0.11b

 

LCAT activity (470/390)

0.23(0.07)

0.24(0.09)

0.09b

TT/TC (n = 22)

 

BMI (kg/m2)

 

Normal

-

-

 
 

Overwight

10(45.5)

16(72.7)

0.032a

 

obese

12(55.5)

6(27.3)

 
 

Waist/Hip

0.96(0.04)

0.93(0.04)

≤0.001b

 

APOA-II/APOA-I

1.49(0.11)

1.31(0.16)

0.002*b

 

HDL(ng/ml)

43.63(8.16)

40.81(6.77)

0.003*b

 

HDL2(ng/ml)

16.08(0.3)

13.84(0.21)

0.005*b

 

HDL3(ng/ml)

28.04(0.24)

28.18(0.24)

0.87b

 

LCAT activity(470/390)

0.22(0.07)

0.24(0.07)

0.35b

CC (n = 22)

 

BMI (kg/m2)

 

Normal

-

2(9)

 
 

Overwight

10(45.5)

12(54.5)

0.032a

 

obese

12(55.5)

8(36.5)

 
 

Waist/Hip

0.97(0.06)

0.93(0.05)

≤0.001b

 

APOA-II/APOA-I

1.44(0.36)

1.48(0.14)

0.58b

 

HDL(ng/ml)

46.18(7.79)

44.71(8.44)

0.04*b

 

HDL2(ng/ml)

14.72(0.29)

14.68(0.34)

0.95b

 

HDL3(ng/ml)

31.99(0.32)

29.34(0.33)

0.03*b

 

LCAT activity(470/390)

0.23(0.08)

0.25(0.10)

0.12b

  1. Values are presented as mean ± standard deviation for continuous and number (%) for categorical variables
  2. BMI Body Mass Index, APOA-I Apolipoprotein A-I, APOA-II Apolipoprotein A-II, HDL High Density Lipoprotein, LCAT Lecithin: cholesterol acyltransferase
  3. For HDL2 and HDL3 Geometric Mean Ratio was used
  4. aUsing the chi-square test, and b Using paired sample t-test
  5. *P value ≤0/05 was considered as statistically significant