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Table 2 Outcome variables before and after intervention in all patients and separately between genotypes

From: The effect of weight loss on HDL subfractions and LCAT activity in two genotypes of APOA-II -265T>C polymorphism

Subjects Variable Before intervention After intervention *P value
Mean(SD) Mean(SD)
Total (n = 44)
  BMI (kg/m2)
  Normal - 2(4.5)  
  Overwight 20(45.5) 28(63.5) ≤0.001a
  obese 24(54.5) 14(32)  
  Waist/Hip 0.97(0.05) 0.93(0.05) ≤0.001b
  APOA-II/APOA-I 1.46(0.26) 1.40(0.17) 0.12b
  HDL(ng/ml) 44.90(7.99) 42.76(7.81) ≤0.001*b
  HDL2(ng/ml) 15.38(0.29) 14.25(0.28) 0.03*b
  HDL3(ng/ml) 29.95(0.29) 28.75(0.28) 0.11b
  LCAT activity (470/390) 0.23(0.07) 0.24(0.09) 0.09b
TT/TC (n = 22)
  BMI (kg/m2)
  Normal - -  
  Overwight 10(45.5) 16(72.7) 0.032a
  obese 12(55.5) 6(27.3)  
  Waist/Hip 0.96(0.04) 0.93(0.04) ≤0.001b
  APOA-II/APOA-I 1.49(0.11) 1.31(0.16) 0.002*b
  HDL(ng/ml) 43.63(8.16) 40.81(6.77) 0.003*b
  HDL2(ng/ml) 16.08(0.3) 13.84(0.21) 0.005*b
  HDL3(ng/ml) 28.04(0.24) 28.18(0.24) 0.87b
  LCAT activity(470/390) 0.22(0.07) 0.24(0.07) 0.35b
CC (n = 22)
  BMI (kg/m2)
  Normal - 2(9)  
  Overwight 10(45.5) 12(54.5) 0.032a
  obese 12(55.5) 8(36.5)  
  Waist/Hip 0.97(0.06) 0.93(0.05) ≤0.001b
  APOA-II/APOA-I 1.44(0.36) 1.48(0.14) 0.58b
  HDL(ng/ml) 46.18(7.79) 44.71(8.44) 0.04*b
  HDL2(ng/ml) 14.72(0.29) 14.68(0.34) 0.95b
  HDL3(ng/ml) 31.99(0.32) 29.34(0.33) 0.03*b
  LCAT activity(470/390) 0.23(0.08) 0.25(0.10) 0.12b
  1. Values are presented as mean ± standard deviation for continuous and number (%) for categorical variables
  2. BMI Body Mass Index, APOA-I Apolipoprotein A-I, APOA-II Apolipoprotein A-II, HDL High Density Lipoprotein, LCAT Lecithin: cholesterol acyltransferase
  3. For HDL2 and HDL3 Geometric Mean Ratio was used
  4. aUsing the chi-square test, and b Using paired sample t-test
  5. *P value ≤0/05 was considered as statistically significant