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Table 3 Characteristics of the diet heart trials

From: The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials

  Allocation Blinding Design Sex Population Prevention Number of participants Age on entry Follow up (Years) Years of the trial
RCOT [21] Random Single Parallel Not reported Free Living Secondary 54 <70 2.0 Not reported
ODHS [22] Random Single Parallel Male Free Living Secondary 412 30-64 5.0 1958-1963
NDHS [29] Random Single & Double Parallel Male Free Living Primary 2032 45-55 1.0 1962-1964
MRCT [23] Random Single Parallel Male Free Living Secondary 393 <60 2.0-7.0 1960-1967
LAVAT [24] Random Double Parallel Male Domiciliary Both 846 ≥55 8.0 1959-1968
FMHS [30, 43, 57]a Assigned by Hospital Single Crossover Both Mental Hospital Primary Both 1635b 10612 34-64/44-64 >15 6.0 1959-1971
SDHS [25] Random Single Parallel Male Free Living Secondary 458 30-59 2.0-7.0 1966-1973
HDAT [31] Random Not reported Parallel Both Free Living Primary 102 Not reported 5.0 1973-1978
MCS [26] Random Double Parallel Both Mental Hospital Both 9057 <30 to >70 4.5 1968-1973
DART [27, 59] Random Single Parallel Male Free Living Secondary 2033 30-69 2.0 1983-1989
STARS [28] Random Single Parallel Male Free Living Secondary 55 <66 3.25 1987-1991c
  1. aData for CHD events in FMHS comes from male and female patients aged 34–64 and 44–64 respectively and “whose initial electrocardiogram was free from coronary patterns”, whereas data for mortality comes from all patients aged >15. bFor an unknown reason, there were five fewer participants for total CHD events compared to major CHD events [57]. cG Watts, personal communication, April 28, 2016