The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials

Table 3 Characteristics of the diet heart trials

	Allocation	Blinding	Design	Sex	Population	Prevention	Number of participants	Age on entry	Follow up (Years)	Years of the trial
RCOT [21]	Random	Single	Parallel	Not reported	Free Living	Secondary	54	<70	2.0	Not reported
ODHS [22]	Random	Single	Parallel	Male	Free Living	Secondary	412	30-64	5.0	1958-1963
NDHS [29]	Random	Single & Double	Parallel	Male	Free Living	Primary	2032	45-55	1.0	1962-1964
MRCT [23]	Random	Single	Parallel	Male	Free Living	Secondary	393	<60	2.0-7.0	1960-1967
LAVAT [24]	Random	Double	Parallel	Male	Domiciliary	Both	846	≥55	8.0	1959-1968
FMHS [30, 43, 57]^a	Assigned by Hospital	Single	Crossover	Both	Mental Hospital	Primary Both	1635^b 10612	34-64/44-64 >15	6.0	1959-1971
SDHS [25]	Random	Single	Parallel	Male	Free Living	Secondary	458	30-59	2.0-7.0	1966-1973
HDAT [31]	Random	Not reported	Parallel	Both	Free Living	Primary	102	Not reported	5.0	1973-1978
MCS [26]	Random	Double	Parallel	Both	Mental Hospital	Both	9057	<30 to >70	4.5	1968-1973
DART [27, 59]	Random	Single	Parallel	Male	Free Living	Secondary	2033	30-69	2.0	1983-1989
STARS [28]	Random	Single	Parallel	Male	Free Living	Secondary	55	<66	3.25	1987-1991^c

^aData for CHD events in FMHS comes from male and female patients aged 34–64 and 44–64 respectively and “whose initial electrocardiogram was free from coronary patterns”, whereas data for mortality comes from all patients aged >15. ^bFor an unknown reason, there were five fewer participants for total CHD events compared to major CHD events [57]. ^cG Watts, personal communication, April 28, 2016

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