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Table 1 Results from earlier meta-analyses

From: The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials

Meta-analysis Search criteria CHD events CHD mortality Total mortality
Skeaff and Miller [14] Altered PUFA/SFA ratio 0.83 (0.69-1.00) 0.84 (0.62-1.12) 0.88 (0.76-1.02)
P = 0.050 P = 0.867 P = 0.083
Mozaffarian et al. [19] Increase in total or n-6 PUFA 0.81 (0.70-0.95) 0.80 (0.65-0.98) 0.98 (0.89-1.08)
P = 0.008 P < 0.05  
Hooper et al.a,b [17] Modified dietary fat 0.82 (0.66-1.02) 0.92 (0.73-1.15) 1.02 (0.88-1.18)
P = 0.073 P = 0.46 P = 0.81
Reduced and modified fat 0.77 (0.57-1.03) 0.98 (0.76-1.27) 0.97 (0.76-1.23)
P = 0.077 P = 0.88 P = 0.78
Chowdhury et al.c [3] n-6 fatty acid supplementation 0.86 (0.69-1.07) - -
Schwingshackl and Hoffmanb [20] PUFA vs. SFA in secondary prevention trials 0.93 (0.72-1.19) 1.05 (0.76-1.44) 0.99 (0.75-1.29)
P = 0.54 P = 0.77 P = 0.91
Harcombe et al.d [4] Reduced or modified fat and published by 1983 or earlier - 0.99 (0.78-1.25) 1.00 (0.87-1.15)
Hooper et al.b [18] Reduced SFA 0.83 (0.72-0.96) 0.95 (0.80-1.12) 0.97 (0.90-1.05)
P = 0.013 P = 0.51 P = 0.47
Ramsden et al.e [5] Main analysis: replaced SFA with mainly n-6 PUFA 1.07 (0.80-1.41) 1.13 (0.83-1.54) 1.07 (0.90-1.27)
Also includes dietary advice only or increased long chain n-3 - 1.00 (0.81-1.24) 1.00 (0.87-1.15)
  1. Data are in relative risk (95% confidence interval). aHooper et al. (2012) categorised trials as replacing modified fat or modified and reduced fat, and performed a separate analysis for each category. bHooper et al. (2012), Schwingshackl & Hoffmann (2014), and Hooper et al. (2015) analysed CVD events and CVD mortality rather than CHD events and CHD mortality. cChowdhury et al. (2014) did not conduct an analysis for CHD mortality or total mortality. dHarcombe et al. (2015) did not conduct an analysis for CHD events. eRamsden et al. (2016) included trials that replaced SFA with mainly n-6 PUFA in their main analysis and conducted a sensitivity analysis that included a further 3 trials that also increased intake of long chain n-3 PUFA in addition to replacing SFA with mainly n-6 PUFA or where participants were only provided with dietary advice