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Table 3 The level of 8-oxo-dG in human serum and cytogenetic damage in human lymphocytes in accordance with lycopene plus β-carotene concentration

From: Possible benefits of tomato juice consumption: a pilot study on irradiated human lymphocytes from healthy donors

  Dose (Gy) Baseline Intake Washout
Mean ± SE Mean ± SE Mean ± SE
8-oxo-dG (A) 0 0.46 ± 0.23 0.32 ± 0.10 0.28 ± 0.10
(ng/mL) 0.1 0.66 ± 0.30 0.52 ± 0.21 0.74 ± 0.35
0.5 0.58 ± 0.30 0.42 ± 0.20 0.48 ± 0.09
2 0.41 ± 0.19 0.34 ± 0.08 0.49 ± 0.17
(B) 0 0.73 ± 0.22 0.45 ± 0.08 0.97 ± 0.46
0.1 0.71 ± 0.21 0.53 ± 0.04 0.76 ± 0.29
0.5 0.45 ± 0.11 0.53 ± 0.12 b 1.04 ± 0.21
2 0.63 ± 0.20 0.77 ± 0.30 0.69 ± 0.20
MN (A) 0 22.10 ± 2.96 17.93 ± 4.45 24.07 ± 4.34
(/1000 BNC) 0.1 22.86 ± 1.93 20.54 ± 1.78 28.91 ± 3.59
0.5 68.98 ± 8.04 54.88 ± 4.87 57.05 ± 8.38
2 281.6 ± 15.6 330.7 ± 26.7 337.9 ± 19.9
(B) 0 20.17 ± 2.97 14.30 ± 3.07 24.94 ± 5.63
0.1 22.43 ± 6.45 20.84 ± 4.32 24.27 ± 3.79
0.5 57.84 ± 7.61 50.06 ± 4.06 53.01 ± 4.19
2 286.6 ± 12.2 300.2 ± 26.7 282.6 ± 17.8
DIC (A) 0 0 0.18 ± 0.18 0
(/500 metaphase) 0.1 0.92 ± 0.49 0.38 ± 0.23 0.78 ± 0.20
0.5 21.31 ± 1.33 19.93 ± 0.87 21.1 ± 1.71
2 98.72 ± 6.24 93.47 ± 4.32 105.4 ± 7.1
(B) 0 0.19 ± 0.19 0 0.19 ± 0.19
0.1 0.32 ± 0.32 0.58 ± 0.39 0.40 ± 0.24
0.5 18.65 ± 1.86 14.99 ± 1.31 a,# 20.86 ± 1.96
2 89.45 ± 6.13 85.64 ± 3.26 $ 99.73 ± 5.60
  1. (A) Group of individuals where the lycopene plus β-carotene concentration was higher than the median value at baseline (>0.635 μg/mL). N = 5 (1 male, 4 females) (B) Group of individuals where the lycopene plus β-carotene concentration was less than the median value at baseline (<0.635 μg/mL). N = 5 (4 males, 1 female) Values are given as mean ± SE of five donors. a: different from the baseline (P < 0.05), b: different from the washout period (P < 0.05), #: different from the washout (P = 0.056), $: different from the washout (P = 0.056) by Wilcoxon signed-ranks test (8-oxo-dG) and paired t test (MN and DIC)