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Table 3 Associations of maternal fatty acid intakes during pregnancy with infant neurodevelopment indices of the BSID-IIat 6 months of age

From: Association between maternal intake of n-6 to n-3 fatty acid ratio during pregnancy and infant neurodevelopment at 6 months of age: results of the MOCEH cohort study

 

MDI

PDI

 

n

β

(SE)

P-value

n

β

(SE)

P-value

n-6 PUFAs, g/d

 Model 1

960

−0.0804

(0.0621)

0.1959

960

−0.0841

(0.0769)

0.2749

 Model 2

669

−0.0969

(0.0698)

0.1659

669

−0.0932

(0.0857)

0.2771

 Model 3

520

−0.1299

(0.0826)

0.1165

520

−0.1611

(0.1011)

0.1116

n-3 PUFAs, g/d

 Model 1

960

0.1142

(0.2680)

0.6702

960

0.0781

(0.3317)

0.8140

 Model 2

669

0.1731

(0.2961)

0.5590

669

0.2856

(0.3629)

0.4317

 Model 3

520

0.1145

(0.3277)

0.7270

520

0.1701

(0.4007)

0.6714

n-6/n-3 PUFAs

 Model 1

960

−0.1354

(0.0612)

0.0271

960

−0.1840

(0.0757)

0.0152

 Model 2

669

−0.1465

(0.0704)

0.0378

669

−0.2097

(0.0862)

0.0152

 Model 3

520

−0.1674

(0.0765)

0.0291

520

−0.1947

(0.0936)

0.0380

LA, g/d

 Model 1

960

−0.0813

(0.0633)

0.1989

960

−0.0821

(0.0783)

0.2950

 Model 2

669

−0.0991

(0.0711)

0.1642

669

−0.0920

(0.0873)

0.2924

 Model 3

520

−0.1342

(0.0844)

0.1123

520

−0.1609

(0.1032)

0.1196

ALA, g/d

 Model 1

960

−0.2199

(0.4868)

0.6515

960

−0.4254

(0.6025)

0.4803

 Model 2

669

−0.2555

(0.5237)

0.6258

669

−0.3763

(0.6421)

0.5581

 Model 3

520

−0.3686

(0.5762)

0.5227

520

−0.7018

(0.7044)

0.3195

LA/ALA

 Model 1

960

−0.1240

(0.0601)

0.0395

960

−0.1839

(0.0744)

0.0135

 Model 2

669

−0.1306

(0.0667)

0.0507

669

−0.1828

(0.0817)

0.0256

 Model 3

520

−0.1567

(0.0724)

0.0310

520

−0.1855

(0.0886)

0.0367

  1. BSID-II Bayley Scales of Infant Development II MDI mental development index PDI psychomotor development index PUFAs polyunsaturated fatty acids LA linoleic acid AA arachidonic acid ALA α-linolenic acid EPA eicosapentanoic acid DHA docosahexaenoic acid LA (18:2n-6) eicosadienoic acid (20:2n-6), dihomo-γ-linolenic acid (DGLA; 20:3n-6), AA (20:4n-6) and docosapentaenoic acid (DPA n-6; 22:5n-6) for the total amount of n-6 fatty acid; and ALA (18:3n-3), eicosatetraenoic acid (ETA; 20:4n-3) EPA (20:5n-3), DPA n-3 (22:5n-3) and DHA (22:5n-3) for the total amount of n-3 fatty acid
  2. Model 1: Unadjusted
  3. Model 2: Adjusted for maternal age, pre-pregnancy BMI, urinary cotinine level (log-transformed), residential area, maternal education level, use of supplements, maternal energy intake (log-transformed), gestational age, infant gender, breastfeeding status and infantile polyunsaturated fatty acid intake (log-transformed)
  4. Model 3: Additionally adjusted for cord blood mercury level (log-transformed)