Glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects

Nutrition Journal

Table 1 Indexes of the metabolic response after ingestion of 25 g of trehalose or glucose

	Fasting values	Cmax	Tmax	IAUC (0–2 h)
Blood Glucose	mg/dL	mg/dL	min	mg/dL∙2 h
Glucose	88 ± 1	154 ± 4	39 ± 2	3185 ± 277
Trehalose	87 ± 1	111 ± 4 **	50 ± 6	1201 ± 202 **
Insulin	μIU/mL	μIU/mL	min	μIU/mL∙2 h
Glucose	3.77 ± 0.34	38.1 ± 3.2	36 ± 2	1709 ± 142
Trehalose	4.25 ± 0.50	15.5 ± 2.5 **	39 ± 4	590 ± 101 **
Active GIP	pmol/L	pmol/L	min	pmol/L∙2 h
Glucose	4.2 ± 0.6	49.9 ± 5.8	19 ± 2	2020 ± 212
Trehalose	4.7 ± 1.6	12.6 ± 2.4**	47 ± 10 *	260 ± 50 **
Active GLP-1	pmol/L	pmol/L	min	pmol/L∙2 h
Glucose	1.7 ± 0.1	4.9 ± 0.8	23 ± 2	93 ± 19
Trehalose	2.0 ± 0.2 *	4.6 ± 0.4	32 ± 3 *	116 ± 19

GIP gastric inhibitory polypeptide, GLP-1 glucagon-like peptide-1
Data are expressed as means ± SE (n = 20). Differences between glucose and trehalose were assessed using a paired Student’s t-test. Significantly different from glucose, *p < 0.05, **p < 0.01

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