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Table 1 Indexes of the metabolic response after ingestion of 25 g of trehalose or glucose

From: Glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects

  Fasting values Cmax Tmax IAUC (0–2 h)
Blood Glucose mg/dL mg/dL min mg/dL∙2 h
 Glucose 88 ± 1 154 ± 4 39 ± 2 3185 ± 277
 Trehalose 87 ± 1 111 ± 4 ** 50 ± 6 1201 ± 202 **
Insulin μIU/mL μIU/mL min μIU/mL∙2 h
 Glucose 3.77 ± 0.34 38.1 ± 3.2 36 ± 2 1709 ± 142
 Trehalose 4.25 ± 0.50 15.5 ± 2.5 ** 39 ± 4 590 ± 101 **
Active GIP pmol/L pmol/L min pmol/L∙2 h
 Glucose 4.2 ± 0.6 49.9 ± 5.8 19 ± 2 2020 ± 212
 Trehalose 4.7 ± 1.6 12.6 ± 2.4** 47 ± 10 * 260 ± 50 **
Active GLP-1 pmol/L pmol/L min pmol/L∙2 h
 Glucose 1.7 ± 0.1 4.9 ± 0.8 23 ± 2 93 ± 19
 Trehalose 2.0 ± 0.2 * 4.6 ± 0.4 32 ± 3 * 116 ± 19
  1. GIP gastric inhibitory polypeptide, GLP-1 glucagon-like peptide-1
  2. Data are expressed as means ± SE (n = 20). Differences between glucose and trehalose were assessed using a paired Student’s t-test. Significantly different from glucose, *p < 0.05, **p < 0.01