Appropriate vitamin D loading regimen for patients with advanced lung cancer

Hoffer, L. John; Robitaille, Line; Swinton, Nelda; Agulnik, Jason; Cohen, Victor; Small, David; Pepe, Carmela; Eintracht, Shaun

doi:10.1186/s12937-016-0203-8

Nutrition Journal

Table 4 Early time-point effects of oral vitamin D loading on plasma 25(OH)D concentrations of adults

From: Appropriate vitamin D loading regimen for patients with advanced lung cancer

First author, year [reference]	Number	Study population	BMI	Intervention	Time point	Mean 25(OH)D concentration	Range or SD
Weisman et al., 1986 [60]	13	Elderly	n.a.	100,000 IU in one dose	Baseline	29
Weisman et al., 1986 [60]	13	Elderly	n.a.	100,000 IU in one dose	14 days	88	SD 14
Ilahi et al., 2008 [54]	30	Healthy volunteers	27	100,00 IU in one dose	Baseline	27
Ilahi et al., 2008 [54]	30	Healthy volunteers	27	100,00 IU in one dose	7–21 days^a	105	SD 20
Romagnoli, 2008 [56]	8	Elderly nursing home	n.a.	300,000 IU in one dose	Baseline	33
					3 days	120	n.a
					7 days	128
					30 days	152
Martineau et al., 2009 [55]	56	Normal volunteers	n.a.	100,000 IU vitamin D2 in one dose	Baseline	34^b
Martineau et al., 2009 [55]	56	Normal volunteers	n.a.	100,000 IU vitamin D2 in one dose	7 days	102	50–140
”	11	Active tuberculosis	n.a.	100,000 IU vitamin D2 in one dose	Baseline	23^b
”	11	Active tuberculosis	n.a.	100,000 IU vitamin D2 in one dose	7 days	133	70–250
Cipriani et al., 2010 [61]	48	Healthy volunteers	24	600,000 IU in one dose	Baseline	35
					3 days	193	SD ~68
					15 days	193
					30 days	155
Amrein et al., 2011 [57]	12	Critically ill	29	540,000 IU in one dose	Baseline	35
					3 days	88	n.a.
					7 days	96	n.a.
Rossini et al., 2012 [58]	13	Elderly	29	100,000 IU in one dose	Baseline	66
					7 days	85	SD ~20
					14 days	83
					30 days	84
”	12	”	29	300,000 IU in one dose	Baseline	64
					7 days	96	SD ~20
					14 days	95
					30 days	86
”	12	”	29	600,000 IU in one dose	Baseline	54
					7 days	156	SD ~30
					14 days	152
					30 days	129
Grossmann et al., 2012 [59]	15	Adults with cystic fibrosis and acute illness	18.5	250,000 IU in one dose	Baseline	76
Grossmann et al., 2012 [59]	15	Adults with cystic fibrosis and acute illness	18.5	250,000 IU in one dose	7 days	145	SD 34
Roth et al., 2012 [62]	34	Non-pregnant women	n.a.	70,000 IU in one dose	Baseline	54
					7 days	79	~45–125
					14 days	75	~40–140
”	27	Pregnant women	n.a.	70,000 IU in one dose	Baseline	39
					7 days	67	~45–100
					14 days	71	~50–120
De Jong et al., 2013 [63]	14	Elderly acute hip fracture	n.a.	150,000 IU as 50,000 IU/day for 3 days	Baseline	30
De Jong et al., 2013 [63]	14	Elderly acute hip fracture	n.a.	150,000 IU as 50,000 IU/day for 3 days	7 days	81	47–108
”	54	”	n.a.	350,000 IU as 50,000 IU/day for 7 days	Baseline	31
”	54	”	n.a.	350,000 IU as 50,000 IU/day for 7 days	7 days	131	86–243
Drincic et al., 2013 [64]	20	Obese	38	10,000 IU per day	Baseline	58
					7 days	80	n.a.
					21 days	106
Cantor, 2014 [65]	18	Internal medicine patients	n.a	356,000 IU as 300,00 IU followed by 4000 IU/day	Baseline	22
Cantor, 2014 [65]	18	Internal medicine patients	n.a	356,000 IU as 300,00 IU followed by 4000 IU/day	14 days	102	50–202
”	32	”	n.a.	206,000 IU as150,000 IU followed by 4000 IU/day	Baseline	55
”	32	”	n.a.	206,000 IU as150,000 IU followed by 4000 IU/day	14 days	108	58–185
Kearns et al., 2015 [66]	14	Healthy volunteers	24	250,000 IU in one dose	Baseline	41
Kearns et al., 2015 [66]	14	Healthy volunteers	24	250,000 IU in one dose	5 days	102	70–149
Oliveri et al., 2015 [67]	11	Healthy volunteers	22	100,000 IU in one dose	Baseline	41	SD 12
Oliveri et al., 2015 [67]	11	Healthy volunteers	22	100,000 IU in one dose	7 days	105
”	11	”	21	100,000 IU vitamin D2 in one dose	Baseline	41	SD 28
”	11	”	21	100,000 IU vitamin D2 in one dose	7 days	92	SD 28
Rousseau et al., 2015 [68]	29	Healthy volunteers	n.a.	100,000 IU in one dose	Baseline	54
Rousseau et al., 2015 [68]	29	Healthy volunteers	n.a.	100,000 IU in one dose	7 days	100	64–167
”	20	Acute burn injury	n.a.	100,000 IU in one dose	Baseline	18
”	20	Acute burn injury	n.a.	100,000 IU in one dose	7 days	48	12–84
Tukvadze et al., 2015 [69]	100	Active tuberculosis	n.a.	50,000 IU three times weekly	Baseline	35
					14 days	175	n.a.
					28 days	225	n.a.
Present study	80	Lung cancer	26	20,000 IU/day for 14 days then 10,000 IU/day	Baseline	48
					14 days	106	16–238
					21 days	116	15–258

BMI body mass index (kg/m²). 25(OH)D concentrations are expressed in nmol/L
^aThe concentration peaked on day 7 and remained approximately constant throughout day 21
^b Sum of 25(OH)D₂ and 25(OH)D₃

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