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Table 1 Fasting and postprandial metabolites and characteristics according to the TNFA-380G → A polymorphism stratified by body mass index in the UK postprandial cohort

From: Association of the tumor necrosis factor-alpha promoter polymorphism with change in triacylglycerol response to sequential meals

 

Normal weight (BMI < 25 kg/m2)

Overweight/obese (BMI ≥ 25 kg/m2)

P *

GG (N = 56)

GA + AA (N = 38)

P a

GG (N = 108)

GA + AA (N = 28)

P a

Age (yrs)

51 ± 2

48 ± 2

0.16

54 ± 1

54 ± 2

0.96

0.09

Gender (men/women)

24/32

10/28

0.10

70/38

18/10

0.96

0.03

BMI (kg/m2)b

23.10 ± 0.20

23.20 ± 0.20

0.21

28.50 ± 0.20

28.00 ± 0.30

0.29

0.03

Fasting metabolites a

TC (mmol/l)

5.46 + 0.13

5.30 ± 0.15

0.97

5.81 ± 0.10

5.85 ± 0.21

0.89

0.97

TAG (mmol/l)

1.27 ± 0.70

1.11 ± 0.07

0.43

1.81 ± 0.09

1.65 ± 0.11

0.36

0.23

HDL-c (mmol/l)

1.48 ± 0.05

1.56 ± 0.07

0.73

1.24 ± 0.04

1.31 ± 0.06

0.37

0.54

LDL-c (mmol/l)

3.39 ± 0.13

3.27 ± 0.15

0.79

3.76 ± 0.09

3.79 ± 0.20

0.89

0.81

Glucose (mmol/l)

4.98 ± 0.07

4.78 ± 0.06

0.31

5.37 ± 0.07

4.99 ± 0.09

0.007

0.006

Insulin (pmol/l)c

36.50 ± 3.70

32.00 ± 4.30

0.51

57.60 ± 3.80

49.20 ± 6.60

0.75

0.54

NEFA (μmol/l)

525 ± 30

493 ± 26

0.39

526 ± 17

494 ± 39

0.59

0.39

HOMA-IRc

1.40 ± 0.20

1.20 ± 0.20

0.43

2.40 ± 0.20

2.00 ± 0.30

0.62

0.44

Postprandial measures a

TAG (mmol/l × 480 min)

AUC

885 ± 51

754 ± 44

0.42

1293 ± 55

1189 ± 78

0.31

0.15

IAUCd

284 ± 26

191 ± 21

0.09

396 ± 24

333 ± 29

0.12

0.02

NEFA (mmol/l × 300 min)e

AUC

147 ± 8

140 ± 7

0.35

157 ± 5

163 ± 7

0.29

0.92

IAUC

92 ± 6

70 ± 16

0.06

102 ± 3

110 ± 6

0.22

0.49

Glucose (mmol/l × 480 min)f

AUC

2943 ± 45

2740 ± 166

0.46

3176 ± 56

2968 ± 153

0.15

0.07

IAUC

564 ± 45

514 ± 55

0.82

590 ± 32

603 ± 60

1.00

0.93

Insulin (nmol/l × 480 min)g

AUC

99 ± 11

117 ± 9

0.37

141 ± 19

149 ± 30

0.28

0.33

IAUC

81 ± 9

99 ± 9

0.41

129 ± 17

122 ± 28

0.47

0.36

  1. Values represent mean ± S.E. mean
  2. As the AA homozygotes were rare (1.7 %), all analyses were conducted by comparing GG homozygotes A allele carriers (GA + AA)
  3. Abbreviations: AUC, area under the curve, BMI body mass index, HDL-c high density lipoprotein cholesterol, HOMA-IR homeostasis model assessment of insulin resistance, IAUC incremental area under the curve, LDL-c low density lipoprotein cholesterol, NEFA non-esterified fatty acids, TAG triacylglycerol, TC total cholesterol
  4. aAdjusted for age, gender, and body mass index
  5. bAdjusted for age, and gender
  6. cBMI < 25, GG (N = 34), A (N = 19); BMI ≥ 25, GG (N = 79), A (N = 19)
  7. dBMI < 25, GG (N = 56), A (N = 37); BMI ≥ 25, GG (N = 106), A (N = 26)
  8. eBMI < 25, GG (N = 36), A (N = 19); BMI ≥ 25, GG (N = 84), A (N = 21)
  9. fBMI < 25, GG (N = 36), A (N = 20); BMI ≥ 25, GG (N = 86), A (N = 22)
  10. gBMI < 25, GG (N = 15), A (N = 7); BMI ≥ 25, GG (N = 35), A (N = 10)
  11. *P values for the difference in the clinical and biochemical parameters between the genotypes in the whole group