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Fig. 2 | Nutrition Journal

Fig. 2

From: The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state

Fig. 2

Some cellular signaling pathways in mammals. Under normal conditions (elevated intracellular reduced potential), nuclear factor erythroid 2-related factor 2 (Nrf2) is stabilized through binding to Keap-1 in the cytoplasm. Under oxidative/nitrosative stress, thiol groups in Keap-1 are oxidized (e.g., S-S cross-links) causing the dissociation of Nrf2, translocation to the nucleus, and binding to the antioxidant-responsive elements (ARE). Depending upon the binding site present in the promoter region, different antioxidant genes are induced

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Nutrition Journal

ISSN: 1475-2891

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