Development and evaluation of a test program for Y-site compatibility testing of total parenteral nutrition and intravenous drugs

Table 3 Composition of paracetamol formulations tested (Source: SmPC of the respective paracetamol products)

Pharmaceutical excipient	Bristol-Myers Squibb^a/Actavis^a	Fresenius Kabi^b	B. Braun^c
Cysteine hydrochloride monohydrate	+	+
Disodium phosphate dihydrate	+
Hydrochloric acid	+
Mannitol	+	+	+
Sodium hydroxide	+
Water for injections	+	+	+
Hydroxyethyl starch			+
Sodium acetate trihydrate			+
Sodium citrate dihydrate			+
Acetic acid, glacial			+
pH	5.5	5.0-7.0	4.5-5.5

a: tested with Olimel® N5E except for PFAT and laser diffraction measurements
b: tested with Kabiven® except for PFAT and laser diffraction measurements
c: tested with SmofKabiven®, all methods + with Olimel® N5E and Kabiven® with regard to PFAT and laser diffraction measurements

ISSN: 1475-2891