Skip to main content

Table 7 Gastrointestinal transit time in subjects with or without lactose intolerance

From: Effects of milk containing only A2 beta casein versus milk containing both A1 and A2 beta casein proteins on gastrointestinal physiology, symptoms of discomfort, and cognitive behavior of people with self-reported intolerance to traditional cows’ milk

  Variable Sequence 1 (n = 22)a Sequence 2 (n = 18)b Estimatec SD P-valued
   Phase 1 Phase 2 Phase 1 Phase 2    
Overall (n = 40) SBTT (h) 3.62 ± 1.46 4.02 ± 1.45 3.90 ± 1.85 3.79 ± 1.89 −0.1997 0.3704 0.593
CTT (h) 35.41 ± 8.68 28.23 ± 5.50 29.62 ± 7.41 35.51 ± 6.92 6.6173 1.2916 <0.0001
WGTT (h) 39.95 ± 8.45 33.41 ± 5.68 34.36 ± 6.90 40.14 ± 6.81 6.2673 1.3568 <0.0001
Lactose intolerant (n = 19) SBTT (h) 3.28 ± 1.31 4.05 ± 1.67 3.81 ± 1.16 4.33 ± 1.79 −0.1262 0.495 0.8018
CTT (h) 31.01 ± 5.92 27.10 ± 3.74 29.06 ± 6.17 32.64 ± 5.85 3.7462 1.3089 0.0108
WGTT (h) 35.40 ± 5.61 32.72 ± 3.16 33.84 ± 6.04 37.85 ± 6.03 3.3441 1.3849 0.0273
Lactose tolerant (n = 21) SBTT (h) 3.81 ± 1.55 4.00 ± 1.37 4.07 ± 2.82 3.27 ± 1.93 −0.4985 0.5583 0.3831
CTT (h) 37.92 ± 9.17 28.87 ± 6.33 30.66 ± 9.95 40.60 ± 6.23 9.494 2.1656 0.0003
WGTT (h) 42.55 ± 8.85 33.80 ± 6.80 35.48 ± 8.89 44.57 ± 6.36 8.9262 2.2947 0.0010
  1. aSequence 1: A1/A2 → A2
  2. bSequence 2: A2 → A1/A2
  3. cLeast squares mean difference (A1/A2 − A2)
  4. dValues in bold are statistically significant at P < 0.05
  5. SD standard deviation, SBTT small bowel transit time, CTT colonic transit time, WGTT whole gastrointestinal transit time