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Table 5 Mixed-effects ANOVA of stool frequency and Bristol Stool Scale scores

From: Effects of milk containing only A2 beta casein versus milk containing both A1 and A2 beta casein proteins on gastrointestinal physiology, symptoms of discomfort, and cognitive behavior of people with self-reported intolerance to traditional cows’ milk

Outcome

Sequencea,b

Contrast

Estimatec

P-valued

P-valuee

Stool frequency

Sequence 1

W1 vs. BL

3.09 ± 3.05

<0.0001

 

W2 vs. BL

3.18 ± 3.79

<0.0001

 

W3 vs. BL

1.55 ± 2.32

0.0127

 

W4 vs. BL

0.09 ± 2.11

0.8828

 

W5 vs. BL

0.45 ± 1.97

0.4613

 

W6 vs. BL

0.05 ± 1.96

0.9412

 

Sequence 2

W1 vs. BL

0.35 ± 1.53

0.5642

<0.001

W2 vs. BL

0.30 ± 2.06

0.6139

0.003

W3 vs. BL

0.04 ± 2.10

0.9425

0.028

W4 vs. BL

0.26 ± 1.54

0.6654

0.759

W5 vs. BL

2.65 ± 3.83

<0.0001

0.021

W6 vs. BL

2.87 ± 3.21

<0.0001

0.001

Bristol Stool Consistency score

Sequence 1

W1 vs. BL

0.49 ± 0.86

0.0031

 

W2 vs. BL

0.37 ± 0.91

0.0261

 

W3 vs. BL

0.23 ± 0.65

0.1588

 

W4 vs. BL

0.03 ± 0.80

0.8445

 

W5 vs. BL

0.03 ± 0.62

0.8753

 

W6 vs. BL

0.01 ± 0.61

0.9687

 

Sequence 2

W1 vs. BL

0.04 ± 0.57

0.818

0.041

W2 vs. BL

−L vs ± 0.67

0.9694

0.120

W3 vs. BL

0.04 ± 0.72

0.818

0.344

W4 vs. BL

−L vs ± 0.73

0.9084

0.826

W5 vs. BL

0.40 ± 0.85

0.0132

0.097

W6 vs. BL

0.26 ± 1.14

0.108

0.358

  1. aSequence 1: A1/A2 → A2
  2. bSequence 2: A2 → A1/A2
  3. cSpecified visit – baseline (mean ± standard deviation)
  4. dVersus baseline; values in bold are statistically significant at P < 0.05
  5. eVersus sequence 1; values in bold are statistically significant at P < 0.05
  6. SD standard deviation, W week, BL baseline