Outcome | Sequencea,b | Contrast | Estimatec | P-valued | P-valuee |
---|---|---|---|---|---|
Stool frequency | Sequence 1 | W1 vs. BL | 3.09 ± 3.05 | <0.0001 | |
W2 vs. BL | 3.18 ± 3.79 | <0.0001 | |||
W3 vs. BL | 1.55 ± 2.32 | 0.0127 | |||
W4 vs. BL | 0.09 ± 2.11 | 0.8828 | |||
W5 vs. BL | 0.45 ± 1.97 | 0.4613 | |||
W6 vs. BL | 0.05 ± 1.96 | 0.9412 | |||
Sequence 2 | W1 vs. BL | 0.35 ± 1.53 | 0.5642 | <0.001 | |
W2 vs. BL | 0.30 ± 2.06 | 0.6139 | 0.003 | ||
W3 vs. BL | 0.04 ± 2.10 | 0.9425 | 0.028 | ||
W4 vs. BL | 0.26 ± 1.54 | 0.6654 | 0.759 | ||
W5 vs. BL | 2.65 ± 3.83 | <0.0001 | 0.021 | ||
W6 vs. BL | 2.87 ± 3.21 | <0.0001 | 0.001 | ||
Bristol Stool Consistency score | Sequence 1 | W1 vs. BL | 0.49 ± 0.86 | 0.0031 | |
W2 vs. BL | 0.37 ± 0.91 | 0.0261 | |||
W3 vs. BL | 0.23 ± 0.65 | 0.1588 | |||
W4 vs. BL | 0.03 ± 0.80 | 0.8445 | |||
W5 vs. BL | 0.03 ± 0.62 | 0.8753 | |||
W6 vs. BL | 0.01 ± 0.61 | 0.9687 | |||
Sequence 2 | W1 vs. BL | 0.04 ± 0.57 | 0.818 | 0.041 | |
W2 vs. BL | −L vs ± 0.67 | 0.9694 | 0.120 | ||
W3 vs. BL | 0.04 ± 0.72 | 0.818 | 0.344 | ||
W4 vs. BL | −L vs ± 0.73 | 0.9084 | 0.826 | ||
W5 vs. BL | 0.40 ± 0.85 | 0.0132 | 0.097 | ||
W6 vs. BL | 0.26 ± 1.14 | 0.108 | 0.358 |