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Table 4 Effects of sequence, time, and intervention on gastrointestinal symptoms

From: Effects of milk containing only A2 beta casein versus milk containing both A1 and A2 beta casein proteins on gastrointestinal physiology, symptoms of discomfort, and cognitive behavior of people with self-reported intolerance to traditional cows’ milk

Outcome

Effecta,b

 

Estimate (log odds ratio)c

SE

95 % confidence limit

P-valued

     

Lower

Upper

 

Bloating

Sequence 1 vs. 2

0.0522

0.8788

−1.6701

1.7745

0.9526

 

Sequence 1

W1 vs. BL

1.7527

0.6363

0.5055

2.9999

0.0059

  

W2 vs. BL

1.6511

0.6742

0.3297

2.9724

0.0143

  

W3 vs. BL

−0.051

0.5686

−1.1655

1.0635

0.9285

  

W4 vs. BL

−0.496

0.8014

−2.0667

1.0748

0.536

  

W5 vs. BL

−0.051

0.7783

−1.5765

1.4745

0.9477

  

W6 vs. BL

−1.2279

1.2429

−3.6639

1.2082

0.3232

 

Sequence 2

W1 vs. BL

0.3289

0.5601

−0.7689

1.4267

0.5571

  

W2 vs. BL

0.2792

0.5768

−0.8513

1.4097

0.6283

  

W3 vs. BL

−0.0479

0.5305

−1.0876

0.9918

0.928

  

W4 vs. BL

−0.0479

0.5305

−1.0876

0.9918

0.928

  

W5 vs. BL

1.9572

0.6713

0.6415

3.2729

0.0036

  

W6 vs. BL

1.7308

0.6743

0.4092

3.0525

0.0103

Abdominal pain

Sequence 1 vs. 2

0.5028

0.9654

−1.3893

2.3949

0.6025

 

Sequence 1

W1 vs. BL

0.6221

0.6176

−0.5884

1.8325

0.3138

  

W2 vs. BL

1.0837

0.5145

0.0754

2.092

0.0352

  

W3 vs. BL

0.3417

0.5903

−0.8152

1.4987

0.5626

  

W4 vs. BL

−0.4568

0.4501

−1.339

0.4255

0.3103

  

W5 vs. BL

0

0.5458

−1.0698

1.0698

1

  

W6 vs. BL

−0.4568

0.4501

−1.339

0.4255

0.3103

 

Sequence 2

W1 vs. BL

−0.735

1.3002

−3.2834

1.8134

0.5719

  

W2 vs. BL

0

1.0937

−2.1436

2.1436

1

  

W3 vs. BL

0

1.0937

−2.1436

2.1436

1

  

W4 vs. BL

0

1.0937

−2.1436

2.1436

1

  

W5 vs. BL

1.3386

0.9439

−0.5114

3.1886

0.1562

  

W6 vs. BL

1.1058

0.8062

−0.4742

2.6859

0.1702

Flatulence

Sequence 1 vs. 2

0

0.8711

−1.7074

1.7074

1

 

Sequence 1

W1 vs. BL

1.0987

0.471

0.1756

2.0218

0.0197

  

W2 vs. BL

1.2275

0.461

0.324

2.131

0.0078

  

W3 vs. BL

−0.3793

0.8025

−1.9521

1.1936

0.6365

  

W4 vs. BL

−1.0965

1.2459

−3.5384

1.3454

0.3788

  

W5 vs. BL

−1.0965

1.2459

−3.5384

1.3454

0.3788

  

W6 vs. BL

−1.0965

1.2459

−3.5384

1.3454

0.3788

 

Sequence 2

W1 vs. BL

0

0.5227

−1.0244

1.0244

1

  

W2 vs. BL

−0.0494

0.5296

−1.0874

0.9885

0.9256

  

W3 vs. BL

−0.4911

0.4293

−1.3325

0.3502

0.2526

  

W4 vs. BL

−0.0494

0.5296

−1.0874

0.9885

0.9256

  

W5 vs. BL

1.5444

0.5457

0.4748

2.6141

0.0047

  

W6 vs. BL

1.1939

0.541

0.1336

2.2542

0.0273

Heavy stomach

Sequence 1 vs. 2

0.1422

0.5364

−0.9091

1.1935

0.791

 

Sequence 1

W1 vs. BL

−0.2612

0.2897

−0.829

0.3067

0.3673

  

W2 vs. BL

−0.0935

0.3705

−0.8197

0.6326

0.8007

  

W3 vs. BL

−0.0935

0.308

−0.6972

0.5102

0.7614

  

W4 vs. BL

−0.2295

0.3383

−0.8925

0.4334

0.4974

  

W5 vs. BL

−0.0587

0.3931

−0.8292

0.7117

0.8812

  

W6 vs. BL

−0.0587

0.3928

−0.8286

0.7111

0.8811

 

Sequence 2

W1 vs. BL

0.0167

0.3576

−0.6841

0.7176

0.9627

  

W2 vs. BL

−0.215

0.3906

−0.9806

0.5507

0.5821

  

W3 vs. BL

−0.1475

0.3687

−0.8702

0.5752

0.6891

  

W4 vs. BL

−0.1475

0.3717

−0.8761

0.5811

0.6915

  

W5 vs. BL

−0.2664

0.5159

−1.2776

0.7448

0.6056

  

W6 vs. BL

−0.1131

0.5352

−1.1621

0.9358

0.8326

Borborygmus

Sequence 1 vs. 2

0.0635

0.6389

−1.1887

1.3157

0.9208

 

Sequence 1

W1 vs. BL

1.337

0.4883

0.3799

2.2941

0.0062

  

W2 vs. BL

1.4152

0.5307

0.3751

2.4553

0.0077

  

W3 vs. BL

0

0.4311

−0.845

0.845

1

  

W4 vs. BL

0.1847

0.456

−0.7092

1.0785

0.6856

  

W5 vs. BL

−0.0619

0.4887

−1.0198

0.896

0.8993

  

W6 vs. BL

0.2874

0.5223

−0.7362

1.311

0.5821

 

Sequence 2

W1 vs. BL

0.1243

0.3335

−0.5293

0.7779

0.7094

  

W2 vs. BL

−0.0606

0.2848

−0.6189

0.4977

0.8315

  

W3 vs. BL

0.2951

0.2606

−0.2157

0.8058

0.2575

  

W4 vs. BL

−0.0606

0.399

−0.8426

0.7214

0.8793

  

W5 vs. BL

2.064

0.4595

1.1634

2.9647

<0.0001

  

W6 vs. BL

1.7846

0.4922

0.8199

2.7494

0.0003

  1. aSequence 1: A1/A2 → A2
  2. bSequence 2: A2 → A1/A2
  3. cBaseline − specified visit
  4. dValues in bold are statistically significant at P < 0.05
  5. SE standard error, BL baseline, W week
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Nutrition Journal

ISSN: 1475-2891

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