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# Table 1 Characteristics of studies investigating the influence of β-palmitate on infant’s health

From: Beta-palmitate – a natural component of human milk in supplemental milk formulas

Authors [Reference] | Patients | Duration of the study | Type of study | Results |
---|---|---|---|---|

Bongers et al., 2007 [25] | 38 constipated infants (3–20 weeks) randomised to standard formula ( | 3 weeks | RCT | Significant tendency towards softer stools in constipated infants fed formula containing |

Carnielli et al., 1995 [18] | Preterm infants ( | 1 week | RCT | A formula containing triglycerides similar to human milk (26 % palmitic acid, esterified predominantly to the |

Carnielli et al., 1996 [11] | Healthy, term infants ( | At least 5 weeks | RCT | Dietary triacylglycerols containing palmitic acid predominantly at the β-position, as in human milk, had significant beneficial effects on the intestinal absorption of fat and calcium in healthy term infants. |

Innis et al., 1994 [2] | Breastfed ( | 3 months | Not specified | 16:0 triacylglycerols were absorbed from human milk similar to |

Kennedy et al., 1999 [20] | Healthy, term neonates fed with standard formula ( | 12 weeks | RCT | Infants receiving high |

Litmanowitz et al., 2013 [21] | 83 term infants fed with high β-palmitate formula ( | 12 weeks | RCT | Infants consuming high β-palmitate formula had changes in the bone speed of sound that were comparable to breastfed infants and favourable compared to infants on low β-palmitate formula. |

Litmanowitz et al., 2014 [30] | Formula-fed infants with high β-palmitate ( | 12 weeks | RCT | Consumption of a high β-palmitate formula, comparable to breast-feeding, affects infant crying patterns during the first weeks of life. |

Lopéz-Lopéz et al., 2001 [3] | 36 healthy full-term infants: 12 infants fed with human milk, 12 infants fed with formula containing 19 % palmitic acid esterified in the β-position (α-formula) for 2 months, 12 infants fed with the α-formula during the first month and with the β-formula (44.5 % palmitic acid in β-position) during the second month | 2 months | RCT of formula-fed infants, non-randomised group of breastfed infants | Consumption of a high β-palmitate formula significantly reduced the contents of total fatty acids and palmitic acid in faeces. |

Lopéz A. et al., 2002 [36] | 120 term infants with different formulas (40 colostrum, 40 transitional milk, 40 mature milk, 11 infant formulas) | 15 days | RCT of formula-fed infants, non-randomised group of breastfed infants | Human milk in Spain had low saturated fatty acids, high monounsaturated fatty acids and high linolenic acid. Infant formulas resemble the fatty acid profile of human milk, but the distribution of fatty acids at the |

Lucas et al., 1997 [27] | 24 preterm infants fed with formula that differed in content of palmitate in the | 4 days | RCT | Use of a formula rich in |

Nelson and Innis, 1999 [15] | 87 healthy, full-term infants (40 breastfed, 22 fed with the standard formula and 25 fed with the formula containing synthesised triacylglycerol (39 % of the 16:0 esterified at the triacylglycerol 2 position). | 120 days | RCT of formula-fed infants, non-randomised group of breastfed infants | 50 % of the dietary triacylglycerol 2-position 16:0 is conserved through digestion, absorption and chylomicron triacylglycerol synthesis in breastfed and formula-fed Infants. Infants fed the synthesised triacylglycerol formula had significantly lower HDL-cholesterol and apolipoprotein A-I and higher apolipoprotein B concentrations than infants fed the standard formula. |

Nowacki et al., 2014 [24] | 165 healthy, term infants fed with standard formula ( | 25–45 days | RCT of formula-fed infants, non-randomised group of breastfed infants | Increasing |

Quinlan et al., 1995 [23] | 20 formula-fed and 10 breastfed infants | 7 days | Single blinded trial | Differences in lipids between formula- and breastfed infants’ stools were due almost entirely to FAs (mainly C16:0 and C18:0) excreted as soaps. FA soaps, predominantly saturated, accounted for one-third of the stool dry weight. These data support the hypothesis that calcium FA soaps are positively related to stool hardness. |

Savino et al., 2006 [29] | 199 formula-fed infants with infantile colic fed with standard formula and simethicone ( | 14 days | RCT | The use of special formula (containing partially hydrolysed whey proteins, prebiotic oligosaccharides with a high β-palmitic acid content) reduced crying episodes in infants with colic compared with a standard formula and simethicone |

Yao et al., 2014 [26] | 300 healthy, formula-fed, term infants, fed with four formulas: standard formula ( | 8 weeks | RCT | High |

Yaron et al., 2013 [34] | 36 term infants: 14 breastfed, 22 formula-fed who were randomly assigned into high β-palmitate ( | 6 week | RCT | High β-palmitate formula beneficially affected infant gut microbiota by increasing the |