Cow’s milk-based beverage consumption in 1- to 4-year-olds and allergic manifestations: an RCT

Nutrition Journal

Table 3 Comparison of immune markers between study groups

Variable^a	Control median (IQR^b)	CMBB median (IQR^b)	p-value*
Fecal Secretory IgA, mg/dL
Baseline	102 (12–226)	67 (7–228)	0.975
Week 28	45 (8–183)	32 (6–153)	0.452
Baseline to Week 28	−1 (−110–28)	−5 (−131–24)	0.664
IL-10, pg/mL
Baseline	19.1 (11.9–27.5)	17.3 (12.0–27.6)	0.760
Week 28	13.9 (9.1–18.6)	13.6 (9.8–19.1)	0.771
Baseline to Week 28	−4.9 (−13.0–3.0)	−.39 (−12.0–0.0)	0.827
TGF-β1, pg/mL
Baseline	20572 (15943–25641)	22386 (17161–29081)	0.109
Week 28	29133 (22432–35466)	29131 (22010–37532)	0.957
Baseline to Week 28	7863 (2569–14178)	6351 (−1346–12472)	0.132
TGF-β2, pg/mL^c
Baseline	344.1 (252.9–479.8)	326.0 (≤262.2–461.7)	0.801
Week 28	438.1 (296.7–600.2)	414.5 (≤331.0–586.3)	0.602
Baseline to Week 28	48.7 (0–123)	48.7 (0–125)	0.465
IL-4, pg/mL^d
Baseline	<1.6 (<1.6- < 1.6)	<1.6 (<1.6- < 1.6)	0.305
Week 28	<1.6 (<1.6- < 1.6)	<1.6 (<1.6- < 1.6)	0.305
IFN-ϒ, pg/mL^d
Baseline	<15.6 (<15.6- < 15.6)	<15.6 (<15.6- < 15.6)	0.368
Week 28	<15.6 (<15.6- < 15.6)	<15.6 (<15.6- < 15.6)	0.378

^aAll markers except fecal secretory IgA were measured in serum
^bIQR = 25–75 % interquartile range
^c28 % of samples were under the detection limit
^dChanges from baseline to week 28 were not analyzed because most of the samples were under detection limit
*Van Elteren test stratified by age category was used for fecal secretory IgA, TGF-β1 and TGF-β2; Kruskal-Wallis test was used for all other immune markers

ISSN: 1475-2891