Table 1 Summary of the knee pain-improving effects of ingested hyaluronan
Study designs | Materials and Methods | Subjects | Results | References |
|---|---|---|---|---|
Randomized, double-blind, placebo-controlled trial | HA mixture at 630 mg (HA 60 mg; MW <5 k) daily for 2 weeks | 24 patients with knee pain (in Japan) | Significant improve of knee pain and discomfort | [34] |
Randomized, double-blind, placebo-controlled trial | HA mixture at 80 mg (HA 48 mg; MW 1000 k) daily for 2 months | 20 patients aged ≥40 years with knee OA (in USA) | Significant improve from baseline for bodily pain bodily pain subscale and physical component summary. | [35] |
Randomized, double-blind, placebo-controlled trial | HA at 240 mg (MW 900 k) daily for 8 weeks | 26 patients aged 50 ~ 65 years with knee pain (in Japan) | Significant improve of knee pain and stiffness | [36] |
Randomized, double-blind, placebo-controlled trial | HA at 200 mg (MW 900 k) daily for 8 weeks | 25 patients with knee OA [WOMAC pain score > 10] (in USA) | Significant improve of tatal WOMAC score and activity of daily living | [37] |
Retrospective cohort study, PCT-controlled trial | HA mixture at 80 mg (HA 48 mg; MW N/A) daily for 6 months | 69 patients with knee OA and synovitis (in Spain) | Significant improve of synovial effusion and knee pain | [38] |
Randomized, double-blind, placebo-controlled trial | HA mixture at 630 mg (HA 60 mg; MW <5 k) daily for 4 months | 40 patients with knee OA and synovitis (in Japan) | Significant improve of pain/step-up and -down function and aggregate total symptoms | [39] |
Randomized, double-blind, placebo-controlled trial | HA mixture at 2520 mg (HA 72 mg; MW <5 k) daily for 12 weeks | 29 patients with knee OA and synovitis (in Japan) | Significant improve of bone metabolism marker | [40] |
Randomized, double-blind, placebo-controlled trial | HA at 200 mg (MW 900 k) daily for 12 months | 38 patients with knee OA (in Japan) | Significant improve of Health condition | [41] |
21patients aged ≦70 years with knee OA (in Japan) | Significant improve of total JKOM score, pain and stiffness in the knee and general activities | |||
Randomized, double-blind, placebo-controlled trial | HA mixture at 80 mg (HA 52 mg; MW N/A) daily for 90 days | 40 healthy individuals with mild joint discomfort (in Spain) | Significant improve of joint mechanics and muscle function | [42] |
Meta-analysis included in two randomized, controlled, double-blind, placebo-controlled trials | HA mixture at 80 mg (HA 48 mg; MW N/A) daily for 3 months | 148 healthy individuals with mild knee pain (in Spain) | Significant improve of muscle function, synovial effusion and reduces pain | [43] |
Randomized, double-blind, placebo-controlled trial | HA mixture at 80 mg (HA 52 mg; MW N/A) daily for 90 days | 68 healthy individuals with mild joint discomfort (in Spain) | Significant improve of articular pain, synovial effusion and knee muscular strength | [44] |
Randomized, double-blind, placebo-controlled trial | HA mixture at 80 mg (HA 56 mg; MW N/A) daily for 3 months | 40 patients with knee OA (in USA) | Significant improve of total WOMAC score and knee pain | [45] |
Randomized, double-blind, placebo-controlled trial | HA mixture daily for 4 weeks (HA 225 mg daily for first 2 weeks, HA 150 mg daily for last 2 weeks; MW 2500 k ~ 2800 k) | 72 patients with knee pain (in USA) | Significant improve of knee pain | [46] |