|
Randomized, double-blind, placebo-controlled trial
|
HA mixture at 630 mg (HA 60 mg; MW <5 k) daily for 2 weeks
|
24 patients with knee pain (in Japan)
|
Significant improve of knee pain and discomfort
|
[34]
|
|
Randomized, double-blind, placebo-controlled trial
|
HA mixture at 80 mg (HA 48 mg; MW 1000 k) daily for 2 months
|
20 patients aged ≥40 years with knee OA (in USA)
|
Significant improve from baseline for bodily pain bodily pain subscale and physical component summary.
|
[35]
|
|
Randomized, double-blind, placebo-controlled trial
|
HA at 240 mg (MW 900 k) daily for 8 weeks
|
26 patients aged 50 ~ 65 years with knee pain (in Japan)
|
Significant improve of knee pain and stiffness
|
[36]
|
|
Randomized, double-blind, placebo-controlled trial
|
HA at 200 mg (MW 900 k) daily for 8 weeks
|
25 patients with knee OA [WOMAC pain score > 10] (in USA)
|
Significant improve of tatal WOMAC score and activity of daily living
|
[37]
|
|
Retrospective cohort study, PCT-controlled trial
|
HA mixture at 80 mg (HA 48 mg; MW N/A) daily for 6 months
|
69 patients with knee OA and synovitis (in Spain)
|
Significant improve of synovial effusion and knee pain
|
[38]
|
|
Randomized, double-blind, placebo-controlled trial
|
HA mixture at 630 mg (HA 60 mg; MW <5 k) daily for 4 months
|
40 patients with knee OA and synovitis (in Japan)
|
Significant improve of pain/step-up and -down function and aggregate total symptoms
|
[39]
|
|
Randomized, double-blind, placebo-controlled trial
|
HA mixture at 2520 mg (HA 72 mg; MW <5 k) daily for 12 weeks
|
29 patients with knee OA and synovitis (in Japan)
|
Significant improve of bone metabolism marker
|
[40]
|
|
Randomized, double-blind, placebo-controlled trial
|
HA at 200 mg (MW 900 k) daily for 12 months
|
38 patients with knee OA (in Japan)
|
Significant improve of Health condition
|
[41]
|
| 21patients aged ≦70 years with knee OA (in Japan) |
Significant improve of total JKOM score, pain and stiffness in the knee and general activities
|
|
Randomized, double-blind, placebo-controlled trial
|
HA mixture at 80 mg (HA 52 mg; MW N/A) daily for 90 days
|
40 healthy individuals with mild joint discomfort (in Spain)
|
Significant improve of joint mechanics and muscle function
|
[42]
|
|
Meta-analysis included in two randomized, controlled, double-blind, placebo-controlled trials
|
HA mixture at 80 mg (HA 48 mg; MW N/A) daily for 3 months
|
148 healthy individuals with mild knee pain (in Spain)
|
Significant improve of muscle function, synovial effusion and reduces pain
|
[43]
|
|
Randomized, double-blind, placebo-controlled trial
|
HA mixture at 80 mg (HA 52 mg; MW N/A) daily for 90 days
|
68 healthy individuals with mild joint discomfort (in Spain)
|
Significant improve of articular pain, synovial effusion and knee muscular strength
|
[44]
|
|
Randomized, double-blind, placebo-controlled trial
|
HA mixture at 80 mg (HA 56 mg; MW N/A) daily for 3 months
|
40 patients with knee OA (in USA)
|
Significant improve of total WOMAC score and knee pain
|
[45]
|
|
Randomized, double-blind, placebo-controlled trial
|
HA mixture daily for 4 weeks (HA 225 mg daily for first 2 weeks, HA 150 mg daily for last 2 weeks; MW 2500 k ~ 2800 k)
|
72 patients with knee pain (in USA)
|
Significant improve of knee pain
|
[46]
|
