Consequences of a high phosphorus intake on mineral metabolism and bone remodeling in dependence of calcium intake in healthy subjects – a randomized placebo-controlled human intervention study

Table 4 Parameters of iron metabolism during the study periods

Parameter	P1000/Ca0	P1000/Ca500	P1000/Ca1000
Plasma iron [pmol/l]
Placebo	17.1±6.5	16.9±7.4	17.1±8.9
4 weeks	15.3±5.8	16.0±7.0	17.4±8.0
8 weeks	16.2±6.2	16.2±5.6	17.0±7.5
Plasma transferrin [g/l]
Placebo	2.7±0.5	2.9^a±0.6	2.9±0.6
4 weeks	2.8±0.4	2.9^a±0.5	3.0±0.6
8 weeks	2.8±0.6	3.1^b±0.7	3.0±0.7
Transferrin saturation [%]
Placebo	22.8±13.3	25.2±13.1	26.6±11.4
4 weeks	22.2±8.6	22.5±9.7	24.6±12.5
8 weeks	24.0±10.6	21.7±7.3	23.9±12.9
Plasma ferritin [pg/d]
Placebo	61.8±73.9	62.9±76.7	57.9±51.7
4 weeks	59.2±61.4	58.2±70.6	59.0±49.8
8 weeks	68.6±66.7	63.0±79.4	52.0±41.1
Fecal iron [pg/g feces]
Placebo	90±40	70±30	80±20
8 weeks	70±30	70±50	60±30

n = 62 for plasma parameter; n = 61 for fecal iron; data are expressed as mean ± standard deviation; P1000/Ca0: 1000 mg phosphorus/0 mg calcium; P1000/Ca500: 1000 mg phosphorus/500 mg calcium; P1000/Ca1000: 1000 mg phosphorus/1000 mg calcium; ^{a b} mean values within a column with dissimilar superscript lower case letters are significantly different (p ≤ 0.05); effect of time was tested using general linear model with repeated measurements (with pairwise comparisons based on Bonferroni); fecal iron was tested with paired and with unpaired Students t-Test within each intervention group and between intervention groups, respectively

ISSN: 1475-2891