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Table 4 Mean change from baseline in study parameters

From: Single-blind, placebo controlled randomised clinical study of chitosan for body weight reduction

  Visit Chitosan
(mean ± SD) [range]
Placebo
(mean ± SD) [range]
P value between groups
Body mass index(Kg/m2) Day 45 (n = 59, 31) -0.69 ± 0.53@ [-2.15 – 0.32] -0.11 ± 0.50 [-1.19 – 1.01] < 0.0001
Day 90 (n = 56, 30) -1.20 ± 0.76@ [-3.65 – 0.73] -0.11 ± 0.59 [-1.81 – 1.14] < 0.0001
Body fat (%) Day 45 (n = 59, 31) -0.38 ± 1.17@ [-6.60 – 2.80] -0.11 ± 1.12 [-3.70 – 2.80] 0.034
Day 90 (n = 56, 30) -0.98 ± 1.27@ [-6.80 – 2.60] -0.05 ± 0.98 [-2.70 – 2.30] < 0.0001
Visceral fat (%) Day 45 (n = 59, 31) -0.38 ± 0.71 [-3.0 – 1.0] -0.19 ± 0.54 [-2.0 – 1.0] 0.127
Day 90 (n = 56, 30) -1.28 ± 1.12@ [-4.0 – 1.0] -0.43 ± 0.85 [-2.0 – 2.0] 0.001
Muscle mass (Kg) Day 45 (n = 59, 31) -0.48 ± 1.51 [-11.10 – 1.20] -0.20 ± 0.89 [-2.50 – 2.70] 0.253
Day 90 (n = 56, 30) −0.74 ± 1.57@ [−11.50 – 1.20] -0.08 ± 1.16 [-3.20 – 3.10] 0.0008
Upper abdominal circumference (cm) Day 45 (n = 59, 31) -0.92 ± 1.25@ [-6.0 – 2.0] -0.35 ± 0.95 [-3.0 – 1.0] 0.020
Day 90 (n = 56, 30) -2.17 ± 1.98@ [-8.0 – 2.0] -0.50 ± 1.10 [-3.0 – 1.0] < 0.0001
Hip circumference (cm) Day 45 (n = 59, 31) -1.05 ± 1.05@ [-4.0 – 0.0] -0.41 ± 1.14 [-4.0 – 2.0] 0.0024
Day 90 (n = 57, 30) -2.07 ± 1.51@ [-6.0 – 2.0] -0.66 ± 1.24 [-3.0 – 2.0] < 0.0001
Waist circumference (cm) Day 45 (n = 59, 31) -0.91 ± 1.68@ [-8.00 – 6.00] -0.64 ± 1.22 [-1.00 – 6.00] 0.027
Day 90 (n = 57, 30) -1.97 ± 2.20@ [-8.00 – 7.00] -0.90 ± 1.47 [-1.00 – 7.00] < 0.0001
Waist to hip ratio Day 45 (n = 59, 31) -0.0027 ± 0.02 [-0.13 – 0.04] -0.0035 ± 0.01 [-0.03 – 0.03] 0.091
Day 90 (n = 57, 30) -0.0010 ± 0.02 [-0.13 – 0.07] -0.0033 ± 0.01 [-0.02 – 0.04] 0.768
  1. Values are expressed as Mean ± Standard deviation (SD); N = Number of subjects in each treatment group; @ - statistically significant when compared to placebo; n = number of patients with non-missing values at respective visit