Skip to main content

Table 4 Mean change from baseline in study parameters

From: Single-blind, placebo controlled randomised clinical study of chitosan for body weight reduction

 

Visit

Chitosan

(mean ± SD) [range]

Placebo

(mean ± SD) [range]

P value between groups

Body mass index(Kg/m2)

Day 45 (n = 59, 31)

-0.69 ± 0.53@ [-2.15 – 0.32]

-0.11 ± 0.50 [-1.19 – 1.01]

< 0.0001

Day 90 (n = 56, 30)

-1.20 ± 0.76@ [-3.65 – 0.73]

-0.11 ± 0.59 [-1.81 – 1.14]

< 0.0001

Body fat (%)

Day 45 (n = 59, 31)

-0.38 ± 1.17@ [-6.60 – 2.80]

-0.11 ± 1.12 [-3.70 – 2.80]

0.034

Day 90 (n = 56, 30)

-0.98 ± 1.27@ [-6.80 – 2.60]

-0.05 ± 0.98 [-2.70 – 2.30]

< 0.0001

Visceral fat (%)

Day 45 (n = 59, 31)

-0.38 ± 0.71 [-3.0 – 1.0]

-0.19 ± 0.54 [-2.0 – 1.0]

0.127

Day 90 (n = 56, 30)

-1.28 ± 1.12@ [-4.0 – 1.0]

-0.43 ± 0.85 [-2.0 – 2.0]

0.001

Muscle mass (Kg)

Day 45 (n = 59, 31)

-0.48 ± 1.51 [-11.10 – 1.20]

-0.20 ± 0.89 [-2.50 – 2.70]

0.253

Day 90 (n = 56, 30)

−0.74 ± 1.57@ [−11.50 – 1.20]

-0.08 ± 1.16 [-3.20 – 3.10]

0.0008

Upper abdominal circumference (cm)

Day 45 (n = 59, 31)

-0.92 ± 1.25@ [-6.0 – 2.0]

-0.35 ± 0.95 [-3.0 – 1.0]

0.020

Day 90 (n = 56, 30)

-2.17 ± 1.98@ [-8.0 – 2.0]

-0.50 ± 1.10 [-3.0 – 1.0]

< 0.0001

Hip circumference (cm)

Day 45 (n = 59, 31)

-1.05 ± 1.05@ [-4.0 – 0.0]

-0.41 ± 1.14 [-4.0 – 2.0]

0.0024

Day 90 (n = 57, 30)

-2.07 ± 1.51@ [-6.0 – 2.0]

-0.66 ± 1.24 [-3.0 – 2.0]

< 0.0001

Waist circumference (cm)

Day 45 (n = 59, 31)

-0.91 ± 1.68@ [-8.00 – 6.00]

-0.64 ± 1.22 [-1.00 – 6.00]

0.027

Day 90 (n = 57, 30)

-1.97 ± 2.20@ [-8.00 – 7.00]

-0.90 ± 1.47 [-1.00 – 7.00]

< 0.0001

Waist to hip ratio

Day 45 (n = 59, 31)

-0.0027 ± 0.02 [-0.13 – 0.04]

-0.0035 ± 0.01 [-0.03 – 0.03]

0.091

Day 90 (n = 57, 30)

-0.0010 ± 0.02 [-0.13 – 0.07]

-0.0033 ± 0.01 [-0.02 – 0.04]

0.768

  1. Values are expressed as Mean ± Standard deviation (SD); N = Number of subjects in each treatment group; @ - statistically significant when compared to placebo; n = number of patients with non-missing values at respective visit