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Table 4 Absolute and relative contribution to total valine flux of endogenous Ra of valine (total flux corrected for exogenous supply), valine oxidation, non-oxidative disposal of valine, total valine and body protein balance, fractional synthesis rate of albumin, serum albumin, and blood urea nitrogen

From: The effect of short-term high versus normal protein intake on whole-body protein synthesis and balance in children following cardiac surgery: a randomized double-blind controlled clinical trial

 

NP [% flux]

HP [% flux]

P-value difference between mediansa

Median difference between groups (95 % CI)b

 

(n = 9)

(n = 11)

  

Total valine flux (μmol · kg−1 · min−1)

2.82 (2.48 to 3.37) [100]

4.26 (3.25 to 5.85) [100]

<0.05

1.38 (1.01 to 1.90)

Valine dietary intake (μmol · kg−1 · min−1)

0.91 (0.86 to 0.97) [32.4]

2.20 (2.01 to 2.30) [52.0]

<0.05

1.28 (1.22 to 1.34)

Endogenous valine Ra (μmol · kg−1 · min−1)

1.90 (1.63 to 2.48) [67.7]

2.06 (1.12 to 3.64) [48.1]

0.50

0.15 (−0.23 to 0.61)

Valine oxidation (μmol · kg−1 · min−1) c

0.68 (0.29 to 1.07) [22.1]

1.58 (0.38 to 2.93) [35.2]

<0.05

0.94 (0.90 to 1.88)

NOD of valine (μmol · kg−1 · min−1) c

2.26 (1.85 to 2.73) [77.9]

2.73 (0.94 to 3.36) [64.9]

0.28

0.37 (−0.55 to 0.88)

Valine balance (μmol · kg−1 · min−1)

0.24 (−0.20 to 0.63)

0.54 (−0.73 to 1.75)

0.57

0.29 (−0.67 to 1.17)

Protein balance (g · kg−1 · d−1)

0.78 (−0.65 to 2.00)

1.73 (−2.35 to 5.59)

0.57

0.94 (−2.15 to 3.74)

FSR albumin (% · d−1)

8.0 (7.1 to 12.0)

9.3 (6.1 to 13.9)

0.20

1.3 (−0.7 to 3.0)

Albumin (g · dL−1)

3.9 (3.7 to 4.5)

3.7 (3.4 to 4.2)

0.13

−0.2 (−0.4 to 0.1)

BUN (mmol · L−1)

4.0 (2.7 to 5.6)

7.1 (4.4 to 11.7)

<0.05

3.3 (2.2 to 4.9)

  1. Values are presented as median (range) absolute [and relative] contribution to total valine flux with estimated differences between groups (confidence interval)
  2. NP normal protein (2 g · kg−1 · d−1) diet, HP high protein (5 g · kg−1 · d−1) diet, CI confidence interval, NOD non-oxidative disposal, Ra rate of appearance, FSR fractional synthesis rate, BUN blood urea nitrogen
  3. aMann–Whitney U test; bHodges-Lehmann procedure; cbased on n = 8 and n = 10 in the NP and HP group, respectively (see text)