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Fig. 3 | Nutrition Journal

Fig. 3

From: Effects of a grape-supplemented diet on proliferation and Wnt signaling in the colonic mucosa are greatest for those over age 50 and with high arginine consumption

Fig. 3

Differences in expression of CyclinD1 (a), AXIN2 (b), cMYC (c) and CD133 (d) in participants below age 50 and 50 years old and above. Prior to grape ingestion, older individuals had significantly higher levels of CyclinD1, AXIN2, cMYC and CD133 than individuals aged 18–49. Grape ingestion in participants aged 50 and above led to a reduction in the expression CyclinD1 (p < 0 · 01), AXIN2, cMYC and CD133. Levels of CyclinD1 and AXIN2 in participants aged 50 and above were reduced to levels seen prior to grape ingestion in 18–49 year olds. While reduced after grape ingestion, the level of expression of cMYC and CD133 in participants aged 50 and above remained significantly elevated when compared to the pre-grape ingestion levels of 18–49 year olds. *p < 0 · 05; **p < 0 · 01; ***p < 0 · 001

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