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Fig. 2 | Nutrition Journal

Fig. 2

From: Effects of a grape-supplemented diet on proliferation and Wnt signaling in the colonic mucosa are greatest for those over age 50 and with high arginine consumption

Fig. 2

Change in individual (a) and mean (b) weights for the 30 participants from pre-grape ingestion timepoint to the post-grape ingestion timepoint. Grape ingestion significantly reduced expression as measured by qRT-PCR of CyclinD1 (c) and CD133 (e) with a non-statistically significant reduction in AXIN2 (d). However, CyclinD1 and AXIN2 levels in colonic mucosa were strongly correlated with each other both pre-grape ingestion (h) and post-grape ingestion (i). Ki67 expression was also reduced following grape ingestion (f). This was measured by calculating the percentage of positively staining cells in the lower 1/3 of colonic crypts (g; representative photomicrograph—green represents positive immunofluorescence). *p < 0 · 05; ** p < 0 · 01; *** p < 0 · 005

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