Relationship of vitamin D status and bone mass according to vitamin D-binding protein genotypes

Nutrition Journal

Table 4 The association between BMD, serum P1NP, serum CTX and age, BMI, gender, 25(OH)D and fetuin-A by multiple regression analysis in subjects stratified by the DBP rs2282679 genotype

	Lumbar spine L1-L4 BMD		Femoral neck BMD		Total hip BMD		Serum P1NP		Serum CTx
	β	p	β	p	β	p	β	p	β	p
A: DBP genotype = CC (n = 98)
Age	-0.13	NS	-0.14	NS	-0.15	NS	-0.25	0.02	-0.20	0.04
BMI	0.23	0.04	0.42	<0.001	0.51	<0.001	0.01	NS	-0.07	NS
Male gender	0.05	NS	0.25	0.01	0.23	0.02	0.08	NS	0.41	<0.001
25(OH)D	0.02	NS	0.01	NS	-0.05	NS	0.05	NS	0.05	NS
Fetuin-A	-0.07	NS	-0.10	NS	-0.08	NS	0.19	0.07	0.16	0.08
B: DBP genotype = CA (n = 637)
Age	-0.09	0.03	-0.21	<0.001	-0.15	<0.001	-0.15	<0.001	-0.19	<0.001
BMI	0.21	<0.001	0.38	<0.001	0.36	<0.001	-0.04	NS	-0.07	0.06
Male gender	-0.03	NS	0.13	<0.01	0.20	<0.01	0.22	<0.001	0.40	<0.001
25(OH)D	0.01	NS	0.02	NS	0.02	NS	-0.01	NS	-0.01	NS
Fetuin-A	0.00	NS	0.04	NS	0.03	NS	0.05	NS	-0.03	NS
C: DBP genotype = AA (n = 999)
Age	-0.08	0.01	-0.19	<0.001	-0.10	<0.01	-0.21	<0.001	-0.23	<0.001
BMI	0.22	<0.001	0.39	<0.001	0.37	<0.001	-0.06	0.07	-0.09	0.003
Male gender	-0.09	0.01	0.13	<0.001	0.15	<0.001	0.28	<0.001	0.46	<0.001
25(OH)D	0.08	0.01	0.10	<0.01	0.08	<0.01	-0.11	0.001	-0.10	0.002
Fetuin-A	-0.04	NS	-0.05	0.08	-0.09	<0.01	0.02	NS	-0.01	NS

ISSN: 1475-2891