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Table 4 Folate, vitamin B12 and Hcy levels according to different polymorphisms in the study groups

From: Folate, Vitamin B12 and Homocysteine status in the post-folic acid fortification era in different subgroups of the Brazilian population attended to at a public health care center

 

GROUPS

RFC1 A80G 3

P 1

GCPII C1651T 4

P 2

MTHFR C677T 5

P 1

 

AA

AG

GG

CC

CT

CC

CT

TT

Folate (ng/mL)

            
 

Elderly

11.2 (8.4,13.2)

11.2 (8.8, 13.9)

11 (8.6, 13.2)

0.840

11 (8.5, 13.7)

12.2 (11.1, 13)

0.252

11.2 (8.6, 13.3)

11 (8.8, 14.2)

10.2 (7.3, 12.4)

0.158

N = 49

N = 125

N = 86

 

N = 241

N = 14

 

N = 103

N = 118

N = 36

Children

12.5 (8.2,16.1)

12.5 (9.4, 15.1)

12.5 (10.2, 14.1)

0.863

12 (9.4, 15.1)

11.5 (8.2, 18.3)

0.932

12.0 (9.3, 14.4)

12.5 (9.2, 14.9)

13.8 (9.6, 15.6)

0.441

N = 20

N = 60

N = 20

 

N = 79

N = 6

 

N = 51

N = 32

N = 11

Pregnant women

9.8 (8.0,13.6)

11 (8.4, 15)

10.9 (8.5, 14.2)

0.346

10.8 (8.2, 14.3)

11.5 (8.5, 13.3)

0.927

11.2 (9, 15)

10.8 (7.7, 14)

8.8 (7.3, 11.6)

0.042

N = 74

N = 129

N = 83

 

N = 250

N = 21

 

N = 139

N = 113

N = 26

Lactating women

10.6 (9.4,12.7)

9.5 (7, 12.1)

9.5 (7.3, 11.7)

0.300

9.8 (7.7, 12)

12.6 (7.5, 14.3)

0.429

10 (9.1, 12.5)

9.3 (7.1, 13.1)

9.7 (6.8, 10.8)

0.723

N = 12

N = 28

N = 14

 

N = 49

N = 3

 

N = 27

N = 21

N = 4

Vitamin B12 (pg/mL)

            
 

Elderly

418 (310, 687.5)

446 (341, 623)

442 (337.5, 584.7)

0.650

444 (333, 616.5)

373.5 (288.2, 647.7)

0.317

463 (345, 594)

431 (330.5, 627.5)

391.5 (276.2, 577.5)

0.443

N = 49

N = 125

N = 86

 

N = 241

N = 14

 

N = 103

N = 118

N = 36

Children

827 (638.5, 1047.5)

874 (650.2, 1200)

770.5 (513, 1207.2)

0.840

901 (611, 1204)

772.5 (518.7, 1000.5)

0.359

790 (572, 1109)

918.5 (660.2, 1206)

756 (553, 1049)

0.333

N = 20

N = 60

N = 20

 

N = 79

N = 6

 

N = 51

N = 32

N = 11

Pregnant women

341.5 (267.7, 462)

324 (253, 419)

319 (240, 412)

0.218

322 (253.7, 424)

324 (263.5, 399.5)

0.738

321 (249, 420)

334 (257.5, 425)

308.5 (236.2, 441.7)

0.703

N = 74

N = 129

N = 83

 

N = 250

N = 21

 

N = 139

N = 113

N = 26

Lactating women

563 (470, 648)

467 (400.2, 540.7)

624 (408.7, 682)

0.114

488 (414, 622.5)

627 (576, 699)

0.094

488 (437, 627)

485 (377, 551.5)

617 (520, 712)

0.137

N = 12

N = 28

N = 14

 

N = 49

N = 3

 

N = 27

N = 21

N = 4

Homocysteine (μmol/L)

            
 

Elderly

14.1 (11.7, 17.9)

12.9 (10.7, 16.4)

13.8 (11.4, 17.2)

0.170

13.5 (11.2, 17.1)

13.3 (10.7, 18.4)

0.896

13.2 (10.9, 15.7)

13.3 (10.8, 17.2)

14.8 (12.1, 18.4)

0.087

N = 49

N = 125

N = 86

 

N = 241

N = 14

 

N = 103

N = 118

N = 36

Children

6.0 (5.3, 6.7)

6.3 (5.1, 7.4)

6.7 (5.2, 7.4)

0.582

6.2 (5.2, 7.1)

5.9 (5.2, 8.4)

0.876

6.2 (5.4, 7.2)

5.8 (4.9, 7.5)

6.8 (6.5, 8)

0.099

N = 20

N = 60

N = 20

 

N = 78

N = 6

 

N = 51

N = 32

N = 11

Pregnant women

5.9 (5.1, 7.6)

6.4 (5.4, 7.6)

6.3 (5.5, 7.5)

0.151

6.4 (5.4, 7.5)

6.2 (5.1, 7.8)

0.710

6.2 (5.4, 7.4)

6.3 (5.2, 7.3)

7.8 (6.3, 9.2)

0.003

N = 74

N = 129

N = 83

 

N = 250

N = 21

 

N = 139

N = 113

N = 26

Lactating women

9.4 (8.2, 10.4)

9.7 (7.4, 11.5)

8.7 (7.8, 10.9)

0.929

9.4 (7.5, 10.8)

12.6 (8.9, 12.6)

0.193

9.4 (7.6, 10.7)

9.9 (8, 11.9)

7.8 (6.8, 11.4)

0.529

N = 12

N = 28

N = 14

 

N = 49

N = 3

 

N = 27

N = 21

N = 4

  1. Values are expressed as median and percentiles (25 and 75).
  2. 1Kruskal-Wallis test.
  3. 2Mann-Whitney test.
  4. 3AA, wild type; AG, heterozygous; and GG homozygous mutant for the RFC1 A80G polymorphism.
  5. 4CC, wild type; and CT, heterozygous for the GCPII C1561T polymorphism.
  6. 5CC, wild type; CT, heterozygous; and TT, homozygous mutant for the MTHFR C677T polymorphism.
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Nutrition Journal

ISSN: 1475-2891

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