Drug | Protein binding | Candidate for free drug |
---|---|---|
Old generation AED | Â | Â |
   Phenobarbital | 40% | No |
   Phenytoin | 90% | Yes |
   Carbamazepine | 80% | Yes |
   Valproic acid | 90-95% | Yes |
   Primidone | 15% | No |
   Ethosuximide | 0% | No |
New generation AED | Â | Â |
   Eslicarbazepine acetate | 30 | No |
   Felbamate | 25 | No |
   Gabapentin | 0 | No |
   Lacosamide | 15 | No |
   Lamotrigine | 55 | No |
   Levetiracetam | 0 | No |
   Oxcarbazepine | 40 | No |
   Pregabalin | 0 | No |
   Rufinamide | 30 | No |
   Stiripentol | 99 | Yes |
   Tiagabine | 96 | Yes |
   Topiramate | 15 | No |
   Vigabatrin | 0 | No |
   Zonisamide | 50 | No |