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Table 3 Protein binding of antiepileptic drugs

From: Selected pharmacokinetic issues of the use of antiepileptic drugs and parenteral nutrition in critically ill patients

Drug

Protein binding

Candidate for free drug

Old generation AED

  

   Phenobarbital

40%

No

   Phenytoin

90%

Yes

   Carbamazepine

80%

Yes

   Valproic acid

90-95%

Yes

   Primidone

15%

No

   Ethosuximide

0%

No

New generation AED

  

   Eslicarbazepine acetate

30

No

   Felbamate

25

No

   Gabapentin

0

No

   Lacosamide

15

No

   Lamotrigine

55

No

   Levetiracetam

0

No

   Oxcarbazepine

40

No

   Pregabalin

0

No

   Rufinamide

30

No

   Stiripentol

99

Yes

   Tiagabine

96

Yes

   Topiramate

15

No

   Vigabatrin

0

No

   Zonisamide

50

No