Table 2 Differences in binding of some antiepileptic drugs to parenteral nutrition fluids and to human serum
Drug | Parenteral nutrition formulas | Fluid †(μmol/L) | Serum (μmol/L) | Average Competitive Binding Difference ‡ |
|---|---|---|---|---|
Carbamazepine | A | 16.1 | 2.1 | 77% |
| Â | B | 16.9 | 1.7 | 82% |
| Â | C | 17.8 | 2.5 | 75% |
| Â | D | 16.9 | 2.1 | 78% |
| Â | E | 17.3 | 2.5 | 75% |
Phenytoin | A | 32.4 | 88.7 | -46% |
| Â | B | 35.0 | 80.6 | -39% |
| Â | C | 34.1 | 74.8 | -37% |
| Â | D | 31.7 | 67.9 | -36% |
| Â | E | 31.7 | 68.3 | -37% |
Phenobarbital | A | 56.8 | 75.9 | -14% |
| Â | B | 58.9 | 74.8 | -12% |
| Â | C | 61.1 | 77.4 | -12% |
| Â | D | 58.5 | 77.4 | -14% |
| Â | E | 61.9 | 78.0 | -12% |
| Â | A | 181.8 | 1290.2 | -75% |
Valproic acid | B | 194.0 | 1179.6 | -72% |
| Â | C | 156.7 | 1061.6 | -74% |
| Â | D | 127.0 | 993.2 | -77% |
| Â | E | 207.6 | 998.1 | -66% |