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Table 5 Serum albumin levels and survival - other cancer sites

From: Pretreatment serum albumin as a predictor of cancer survival: A systematic review of the epidemiological literature

First author, year of publication, place Year of data collection Study design, Sample size Cancer type Groups being compared RR (95%Cl), p-value Variables adjusted for
Barreto-Andrade JC, 2009, Mexico [87] January 1986 to May 2006 Retrospective, 61 Soft Tissue Sarcoma Low <3.5 g/dL
Normal >=3.5 g/dL
Univariate: p = 0.03
Multivariate: p = 0.02
Age, sex, obesity, previous biopsy performed, histology, site histologic grade, stage, tumor resectability, tumor size, performance status, surgical risk
Seve P, 2006, France [47] January 1, 1998 to December 31, 2004 Retrospective consecutive case series, 317 Unknown Primary Low <3.5 g/dL
Normal >=3.5 g/dL
Univariate: Median survival in days
Low: 62; Normal: 318; p < 0.0001
Multivariate: 2.70 (1.79-4.07), <.0001
Age, sex, ACE-27 score, No. of sites, liver metastasis, peritoneal mets, PS, LDH, ALP, hemoglobin, platelets
Alici S, 2003, Turkey [88] 1989 to 1998 Retrospective, 110 Non-Hodgkin's Lymphoma Normal
Low
Univariate: p = 0.005
Multivariate: p = 0.022
Age, sex, stage, PS, B symptoms, treatment regimen, remission status, histology, bulky disease, LDH, ESR, extranodal involvement
Medow MA, 2002, USA [89] July 1993 to June 1997 Retrospective consecutive case series, 406 Head and neck <3.85 g/dL
>=3.85 g/dL
TNM stage IV or recurrent disease
Median survival:
<3.85 g/dL: 404 days (286-532 days),
>=3.85 g/dL: 625 days (536-1032 days)
Age, tumor stage, self-reported functional class, systolic blood
pressure, diastolic blood pressure, and BMI
Ljungberg B, 2000, Sweden [90] April 1982 to February 1999 Retrospective consecutive case series, 106 Renal cell Continuous variable Univariate: NA, p = 0.063
Multivariate: 1.01 (0.45 - 2.28), 0.96
Age, gender, tumor size, PS, solitary metastases, calcium, ESR, nuclear grade, DNA ploidy and vein invasion
Schwartzbaum JA, 1999, USA [91] February 1, 1993 to December 31, 1995 A convenience sample, 24 Glioblastoma multiforme 1st Quartile
(2.6-3.1 g/dL)
2nd Quartile
3rd Quartile
4th Quartile
(3.9-4.4 g/dL)
Multivariate:
2nd= 1.2
3rd= 0.1
4th =0.1
p = 0.007
Age, sex, chemotherapy, serum iron, radiation
Aparicio J, 1998, Spain [92] 1970 to 1993 Retrospective, 116 Ewing's sarcoma Low: <=3.5 g/dL
Normal: >3.5 g/dL
Univariate: 5 year survival 48% in normal and 7% in low; median survival 52 months in normal and 6 months in low, p < 0.0001
Multivariate: p = 0.001
Age, sex, tumor site, maximum tumor diameter, extent of disease, PS, duration of symptoms before diagnosis, systemic symptoms, leukocytes and hemoglobin, ESR, LDH, histologic pattern, percent of tumor necrosis on the initial biopsy specimen
Citterio G, 1997, Italy [93] 1988 onwards Retrospective consecutive case series, 109 Renal cell NA Univariate: p < 0.01 Age, sex, DFI, PS, stage at diagnosis, grading, number and type of metastatic sites, nephrectomy, blood levels of hemoglobin, creatinine, calcium, LDH, ferritin, ALP, triglycerides