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Table 3 Serum albumin and survival - female cancers

From: Pretreatment serum albumin as a predictor of cancer survival: A systematic review of the epidemiological literature

First author, year of publication, place Year of data collection Study design, Sample size Cancer type Groups being compared RR (95%Cl), p-value Variables adjusted for
Gupta D, 2009, USA [77] January 2001 to May 2006 Retrospective, consecutive case series, 213 Ovarian >=3.5 g/dL <3.5 g/dL Used as continuous as well Univariate: median survival in months (95%CI) Low: 7.3 (4.8 to 9.8) Normal: 23.3 (16.5 to 30.1); p < 0.0001 Multivariate: 0.39 (0.29-0.53), <0.001 Age, BMI, CA125, tumor stage, treatment history
Sharma R, 2008, UK [78] October 2003 to June 2006 Retrospective, 154 Ovarian <3.5 g/dL >=3.5 g/dL Univariate: 1.71 (0.92-3.18), 0.091 GPS score was prognostic on multivariate analysis Tumor type, stage, grade, ascites, debulking surgery, ALP, residual disease, CRP
Alphs HH, 2006, USA [79] January 1, 1990 to June 30, 2004 Retrospective, 78 Ovarian and primary peritoneal >=3.7 g/dL <3.7 g/dL Univariate: 0.58 (0.42-0.79), p < 0.00 Multivariate: 0.60 (0.41-0.89), p = 0.01 Age, race, BMI, Co-morbidity index, surgeon, ASA score, tumor size, intraoperative blood loss, ascites
Lis CG, 2003, USA [46] March 1993 to December 1999 Retrospective consecutive case series, 180 Breast >=3.5 g/dL <3.5 g/dL Multivariate: 3.53, 0.0033 Abnormal breast antigen, tumor stage, abnormal HER2/Neu readings
Wyld L 2003, UK [80] January 1997 to January 2002 Retrospective, 145 Breast cancer with liver metastases First group <3.0 g/dL >=3.0 g/dL Second group <3.5 g/dL >=3.5 g/dL Median survival in months (95%CI) For first group >=3.0 g/dL = 5.86 (0.16 - 51) <3.0 g/dL = 1.5 (0.16 - 5.13), p = 0.01 For Second group >=3.5 g/dL = 7.0 (0.27 - 51) <3.5 g/dL = 2.0 (0.16 - 27.2) p = 0.01 LFTs, CEA, bilirubin, age, histological grade, ER status, metastasis, treatment response
Clark TG, 2001, UK [81] 01/01/1984 to 31/12/1999 Retrospective, 1189 Ovarian Continuous variable Univariate: p <= 0.05 Multivariate: 0.97 (0.96, 0.99), 0.036 Age, FIGO stage, the presence or absence of ascites, performance status, histology, debulking, grade, CA125 and ALP