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Table 2 Serum albumin and survival - lung cancer

From: Pretreatment serum albumin as a predictor of cancer survival: A systematic review of the epidemiological literature

First author, year of publication, place Year of data collection Study design, Sample size Cancer type Groups being compared RR (95%Cl), p-value Variables adjusted for
Win T, 2008, UK [70] 2 years up to December 2006 Prospective consecutive case series, 110 Non Small Cell Lung Continuous variable Univariate: 0.93 (0.88-0.98), 0.006 Female gender, age, pneumectomy, chronic obstructive pulmonary disease, Smoking, Diabetes, Coronary disease, BMI, global quality of life
Forrest LM, 2005, UK [71] January 2002 to December 2003 Prospective, 101 Non Small Cell Lung >=3.5 g/dL <3.5 g/dL Median Survival (months) (95% CI) For >/=3.5 g/dL = 8.7 (6.9-10.5) For <3.5 g/dL = 1.2 (0.0-2.8), p = <0.01 Age, sex, stage, hemoglobin, WBC, CRP, PS, GPS, treatment
Maeda T, 2000, Japan [9] 1978-1992 Retrospective, 261 Non Small Cell Lung <3.5 g/dL >=3.5 g/dL Median survival in months <3.5 g/dL = 5.0 >=3.5 g/dL = 9.6; p = <0.001 Multivariate: 1.69 (1.19-2.41), 0.0037 Age, gender, histology, PS, LFTs, Stage IV, bilirubin, CEA, liver metastases
Tas F, 1999, Turkey [10] 1991 to 1997 Retrospective, 207 Small Cell Lung Normal: >=3.5 g/dL Low: <3.5 g/dL Univariate: p = <0.001 Multivariate: p = 0.03 Age, gender, performance status, weight loss, clinical stage, hemoglobin, LDH, response to chemotherapy
Ray P, 1998, France [4] NA Retrospective, 99 patients with SCLC and 202 patients with NSCLC Small cell lung and Non-Small cell lung NA Serum albumin levels were not found to be associated with survival Tumor, node, metastasis status, PS, body weight loss, WBC, serum sodium, LDH, ALP, serum NSE, serum TPS, and CYFRA 21-1
Lai SL, 1998, Taiwan [72] NA Prospective, 150 Non Small Cell Lung NA Patients who died within six months after diagnosis had significantly lower values of all nutritional parameters than those who survived more than 6 months Weight/height ratio, percent of standard triceps skin-fold thickness, percent of standard arm muscle circumference, transferrin, creatinine height index and total lymphocyte count
Maestu I, 1997, Spain [73] November 1981 to January 1993 Retrospective, 341 Small cell lung <3.4 g/dL >=3.4 g/dL Univariate: 0.0057 Multivariate : coefficient = -0.3457, p = 0.001 LDH, disease extent, CK, neutrophils, PS, glycemia, ESR, sodium, potassium, ALP, urea, uric acid, age
Muers MF, 1996, UK [74] NA Retrospective consecutive case series, 207 Non Small Cell Lung NA Prognostic Index = -0.42 × distant metastases + 1.1 × hoarseness + 0.47 × malaise - 0.34 × immediate treatment intent + 0.72 × lymphocyte count + 0.94 × serum albumin + 0.62 × sodium - 0.98 × ALP Sex, the activity score, the presence of malaise, hoarseness and distant metastases at presentation, and lymphocyte count, sodium and ALP levels
Hespanhol V, 1995, Portugal [75] 1984 to 1990 Prospective, 411 Non Small Cell Lung <3.5 g/dL >=3.5 g/dL Univariate: 1.92, (1.55-2.36), 0.000 Multivariate: 0.588 (0.46-0.74), 0.000 PS, Weight loss, Hoarseness, stage, lymphocyte, LDH, sex
Espinosa E, 1995, Spain [76] 1980-1992 Retrospective onsecutive case series, 292 Non Small Cell Lung >=4 g/dL <4 g/dL Univariate: Median survival in months For >=4 g/dL = 9 For <4 g/dL = 7, p = 0.004; Multivariate: Coefficient = -2.52, p = 0.0001 Number of metastases, LDH, PS, sedimentation rate