Table 2 Serum albumin and survival - lung cancer
First author, year of publication, place | Year of data collection | Study design, Sample size | Cancer type | Groups being compared | RR (95%Cl), p-value | Variables adjusted for |
|---|---|---|---|---|---|---|
Win T, 2008, UK [70] | 2 years up to December 2006 | Prospective consecutive case series, 110 | Non Small Cell Lung | Continuous variable | Univariate: 0.93 (0.88-0.98), 0.006 | Female gender, age, pneumectomy, chronic obstructive pulmonary disease, Smoking, Diabetes, Coronary disease, BMI, global quality of life |
Forrest LM, 2005, UK [71] | January 2002 to December 2003 | Prospective, 101 | Non Small Cell Lung | >=3.5 g/dL <3.5 g/dL | Median Survival (months) (95% CI) For >/=3.5 g/dL = 8.7 (6.9-10.5) For <3.5 g/dL = 1.2 (0.0-2.8), p = <0.01 | Age, sex, stage, hemoglobin, WBC, CRP, PS, GPS, treatment |
Maeda T, 2000, Japan [9] | 1978-1992 | Retrospective, 261 | Non Small Cell Lung | <3.5 g/dL >=3.5 g/dL | Median survival in months <3.5 g/dL = 5.0 >=3.5 g/dL = 9.6; p = <0.001 Multivariate: 1.69 (1.19-2.41), 0.0037 | Age, gender, histology, PS, LFTs, Stage IV, bilirubin, CEA, liver metastases |
Tas F, 1999, Turkey [10] | 1991 to 1997 | Retrospective, 207 | Small Cell Lung | Normal: >=3.5 g/dL Low: <3.5 g/dL | Univariate: p = <0.001 Multivariate: p = 0.03 | Age, gender, performance status, weight loss, clinical stage, hemoglobin, LDH, response to chemotherapy |
Ray P, 1998, France [4] | NA | Retrospective, 99 patients with SCLC and 202 patients with NSCLC | Small cell lung and Non-Small cell lung | NA | Serum albumin levels were not found to be associated with survival | Tumor, node, metastasis status, PS, body weight loss, WBC, serum sodium, LDH, ALP, serum NSE, serum TPS, and CYFRA 21-1 |
Lai SL, 1998, Taiwan [72] | NA | Prospective, 150 | Non Small Cell Lung | NA | Patients who died within six months after diagnosis had significantly lower values of all nutritional parameters than those who survived more than 6 months | Weight/height ratio, percent of standard triceps skin-fold thickness, percent of standard arm muscle circumference, transferrin, creatinine height index and total lymphocyte count |
Maestu I, 1997, Spain [73] | November 1981 to January 1993 | Retrospective, 341 | Small cell lung | <3.4 g/dL >=3.4 g/dL | Univariate: 0.0057 Multivariate : coefficient = -0.3457, p = 0.001 | LDH, disease extent, CK, neutrophils, PS, glycemia, ESR, sodium, potassium, ALP, urea, uric acid, age |
Muers MF, 1996, UK [74] | NA | Retrospective consecutive case series, 207 | Non Small Cell Lung | NA | Prognostic Index = -0.42 × distant metastases + 1.1 × hoarseness + 0.47 × malaise - 0.34 × immediate treatment intent + 0.72 × lymphocyte count + 0.94 × serum albumin + 0.62 × sodium - 0.98 × ALP | Sex, the activity score, the presence of malaise, hoarseness and distant metastases at presentation, and lymphocyte count, sodium and ALP levels |
Hespanhol V, 1995, Portugal [75] | 1984 to 1990 | Prospective, 411 | Non Small Cell Lung | <3.5 g/dL >=3.5 g/dL | Univariate: 1.92, (1.55-2.36), 0.000 Multivariate: 0.588 (0.46-0.74), 0.000 | PS, Weight loss, Hoarseness, stage, lymphocyte, LDH, sex |
Espinosa E, 1995, Spain [76] | 1980-1992 | Retrospective onsecutive case series, 292 | Non Small Cell Lung | >=4 g/dL <4 g/dL | Univariate: Median survival in months For >=4 g/dL = 9 For <4 g/dL = 7, p = 0.004; Multivariate: Coefficient = -2.52, p = 0.0001 | Number of metastases, LDH, PS, sedimentation rate |