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Table 3 Questionnaire scores before and after active (high cocoa liquor/polyphenol rich chocolate) and placebo (simulated iso-calorific chocolate - cocoa liquor free/low polyphenol)

From: High cocoa polyphenol rich chocolate may reduce the burden of the symptoms in chronic fatigue syndrome

Questionnaires Before Intervention After Intervention (8 weeks) Wilcoxon Signed Rank Sum test
  Median (Range) Median (Range) Z value (Exact Sig. (2-tailed))
Chalder Fatigue questionnaire Active Arm 33 (25 - 38) 21.5 (6 - 35) -2.53 (0.01)
Chalder Fatigue questionnaire Placebo Arm 28.5 (17 - 20) 34.5 (13-26) -2.23 (0.03)
HAD questionnaire (Anxiety) Active Arm 9.5 (8-13) 6 (4-8) -2.54 (0.01)
HAD questionnaire (Anxiety) Placebo Arm 6 (3-9) 9 (8-12) -2.21 (0.03)
HAD questionnaire (Depression) Active Arm 10 (9-14) 5.5 (4-9) -2.68 (0.01)
HAD questionnaire (Depression) Placebo Arm 6 (4-9) 12 (8-14) -2.34 (0.02)
LHS questionnaire (residual function) Active Arm 0.49 (0.33 - 0.62) 0.64 (0.44 - 0.83) -2.52 (0.01)
LHS questionnaire (residual function) Placebo Arm 0.44 (0.43 - 0.68) 0.36 (0.33 - 0.62) -2.21 (0.03)