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Table 6 Trials testing magnesium

From: Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review

Reference Study Design Sample Population Intervention Control Length of Treatment Outcomes Direction of Evidence Reported Adverse Events
Carroll (2000) [75] Randomized; Double-blind; Parallel Group 80 healthy males Berocca: oral multivitamin1 Placebo 28 days Multivitamin treatment significantly reduced anxiety as measured by GHQ-28, HADS and PSS. + Not reported
De Souza (2000) [76] Randomized; Double-blind; Crossover (4) 44 women with adverse premenstrual symptoms but otherwise in good health (1) 200 mg Mg, (2) 50 mg vitamin B6, (3) 200 mg Mg + 50 mg vitamin B6 per day Placebo One menstrual cycle 200 mg/day Mg + 50 mg/day vitamin B6 significantly reduced anxiety-related premenstrual symptoms + Participants were not specifically asked, but none were reported spontaneously
Hanus (2004) [77] Randomized;
Double-blind;
Parallel Group
264 patients with generalized anxiety (DSM-III-R) of mild-to-moderate intensity2 Sympathyl: extracts of crataegus oxyacantha and eschscholtzia californica plus magnesium Placebo 3 months Significant clinical improvement in anxiety3 in favour of the combination treatment + No serious AEs related to treatment4
  1. GHQ-28: General Health Questionnaire; HADS: Hospital Anxiety and Depression Scale; PSS: Perceived Stress Scale; DMS-II-R: Diagnostic and Statistical Manual of Mental Disorders, third edition revised; HAMA: Hamilton Anxiety Scale; HAMA-SOM: Hamilton Anxiety Scale, subscore somatic anxiety; HAMA-T: Hamilton Anxiety Scale, total score (HAMA-T
  2. 1. Multivitamin containing vitamin B1 (15 mg), B2 (15 mg), niacin (50 mg), pantothenic acid (23 mg), B6 (10 mg), biotin (150 mcg), folic acid (400 mcg), B12 (10 mcg), C (500 mg), calcium (100 mg), magnesium (100 mg), zinc (10 mg).
  3. 2. Total HAMA score between 16 and 28.
  4. 3. Measured by HAMA-T and HAMA-SOM and subjective patient-rated anxiety.
  5. Headache, muscular stiffness, insomnia, drowsiness, indifference, anxiety, palpitations, nausea (4), gastralgia, diarrhea, gastric heaviness, dysuria, colic renal pain, morning sluggishness (3), asthenia.