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Table 2 Trials testing passionflower

From: Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review

Reference Study Design Sample Population Intervention Control Length of Treatment Outcomes Direction of Evidence Reported Adverse Events
Bourin (1997) [34] Randomized;
Double-blind;
Parallel Group
182 outpatients with adjustment disorder with anxious mood Euphytose1; 2 tablets, 3 times a day Placebo tablets 28 days Significant reduction in HAMA scores (from D7 to D28) in favour of Euphytose treatment + No serious AEs.
Dry mouth
Headache
Constipation
Drowsiness
Akhondzadeh (2001) [32] Randomized;
Double-blind; Parallel group
36 outpatients with DSM-IV for GAD for at least 6 months 45 drops/day of Passiflora extract plus placebo tablet Oxazepam 30 mg/day plus placebo drops 4 weeks Decrease in HAMA for both treatments2; overall no
significant difference in efficacy between treatments
+ Higher impairment of job performance in oxazepam group; overall no significant difference in total side effects3
Movafegh (2008) [33] Randomized;
Double-blind; Parallel Group
60 patients undergoing inguinal herniorrhaphy Oral Passiflora incarnata (500 mg, Passipy™ IranDarouk) Placebo Given as pre-medication 90 minutes before surgery NRS anxiety scores were significantly
lower in the passiflora group
+ Not reported
  1. AEs: Adverse events; HAMA: Hamilton Anxiety Scale; DMS-IV: Diagnostic and Statistical Manual of Mental Disorders, fourth edition; GAD: generalized anxiety disorder; NRS: numerical rating scale.
  2. 1. Combination of Crataegus oxyacantha (10 mg), Ballota foetida (10 mg), Passiflora incarnata (40 mg), Valeriana officinalis (50 mg), Cola nitida (15 mg) and Paullinia cupana (15 mg).
  3. 2. D4 oxazepam; D7 passiflora.
  4. 3. Passiflora, mild/moderate: Dizziness, Drowsiness, Confusion, Ataxia, Allergic reaction, Impairment of job performance.