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Table 1 Genes regulated by body weight/diet and alcohol consumption.

From: Effects of body weight and alcohol consumption on insulin sensitivity

Category/Gene

Change

 

Water

Alcohol

 

CR

LF

HF

CR

LF

HF

Metabolism

   Lep

-5.5

1

2.9

-3.1

1.8

2.6

   Fbp2

-1.4

1

1.4a

-1.6

-1.8

1.5a

   Gck

2.7

1

-2.9

2.6

2.3

-1.8

   Ins1

3.9

1

-2.5

2.8

2.5

-2.7

   Pltp

2.4

1

1.0a

2.5

1.9

1.2a

   Apob

4.4

1

-1.7

3.6

1.6

-1.3a

   Pck1

-1.5

1

1.4a

-1.6

-1.7

1.5

   Ppp1r3a

-1.8

1

1.4a

-1.5

1.6

1.4

   Aldh3a2

11

1

-5.8

9.5

3.1

-3.8

   Lpin3

1.1a

1

3.4

1.0a

1.5

2.6

   Lepr

-1.6

1

4

1.1a

1.5

2.4

   Lpin2

8.3

1

-3.3

7.1

2.2

-2.3

   Mlxipl

1.2a

1

-1.9

1.1a

1.8

-1.6

   Apoa4

4.1

1

1.0a

4.2

1.7

1.1a

   Mthfr

-2.5

1

1.1a

-2.4

-2.9

-1.2a

   Akt2

2.1

1

1.1a

2

2

1.1a

   Flot2

2.4

1

-1.3a

2.2

2.1

-1.2a

   Nmu

-1.4a

1

3.3

1.2a

-1.6

2.7

   Adrbk1

5.7

1

-1.3a

4

2.5

1.1a

   Sst

2.9

1

-1.1a

2.5

2.5

1.1a

   Adrb2

7.8

1

1.5

5.9

1.6

1.3a

   Prl

11

1

-4

9

2.3

-2.4

   Npy2r

3.2

1

1.2a

2.4

2

1.2a

Pro-inflammation

   Cd68

1.0a

1

4.3

1.9

1.5

2.8

   Ccr2

8.3

1

-1.4a

7.1

2.9

-1.4a

Anti-inflammation

   Il10

4

1

1.5a

4.8

2.7

1.2a

   Ptgds

3.7

1

1.1a

3.5

1.6

1.2a

   Adrbk1

5.7

1

-1.3a

4

2.2

1.1a

Signal transducers, Growth factors

   Raf1

1.0a

1

2.1

1.0a

2.1

2.3

   Pde3b

-1.8

1

2.1

-1.8

-2.2

1.7

   Pde3a

3.2

1

-1.1a

2.9

1.6

-1.2a

   Gne

2.9

1

-1.1a

2.9

2.2

1.1a

   Ptpn2

2.8

1

1.1a

1.8

1.5

-1.1a

   Cblb

1.6a

1

-2.3

2.8a

3.4

-1.1a

   Ptpn6

2.4

1

-1.6

1.8

1.8

-1.4

   Ppp1cb

-1.8

1

1.8

-1.8

-1.4

1.6

   Dusp9

19.2

1

-1.7

17

3.1

-1.2a

   Itgb3

2.5

1

1.1a

2.4

2.4

1.2a

   Prkx

5.9

1

2.9

4.3

2.3

1.8

   Prkcz

4.3

1

-1.8

4.5

3.2

1.0a

   Nras

5

1

-1.8

4

2

-1.6

   Igfbp3

2.4

1

1.2a

2

3.1

1.0a

Miscellaneous

   Eif4ebp2

4.5

1

-2.1

2.9

2.2

-1.6

   Serpina6

3.5

1

-2.1

1.8

1.6

-1.7

   Atp2a3

2.9

1

1.1a

3.3

2.5

1.2a

   Stx1a

2.6

1

-1.6

1.9

1.5

-1.5a

   Alms1

2.5

1

1.1a

2.8

2

1.2a

   Sct

-2.8

1

1.0a

-2.6

-2

1.0a

   Unc13a

3.6

1

-1.4a

2.7

1.5

-1.4a

   Alb

3.3

1

-4

3.5

2.7

-3.4

   Bbs1

1.0a

1

2.2

-1.2a

-1.7

1.8

  1. a No significant change compared to Control. All others were significantly different compared to control mice, p < 0.05.