A natural mineral supplement provides relief from knee osteoarthritis symptoms: a randomized controlled pilot trial

Table 3 Changes in WOMAC Scores at baseline and at the end of the trial Between and Within Groups (ITT-LOCF)

Variable	Pain Baseline	Pain End	Pain baseline – pain end	Stiffness Baseline	Stiffness End	Stiffness baseline – stiffness end	Activity Baseline	Activity End	Activity baseline – activity end	Composite Baseline	Composite End	Composite baseline – composite end
PBO	50.0	52.9	-2.9	40.4	46.3	-5.9	49.4	56.4	-7.0	48.8	54.8	-6.1
SD	22.9	21.4	19.9	17.4	25.3	18.3	23.1	24	18.4	21.8	22.7	17.6
Sig.*			NS			NS			NS			NS
A	56.8	74.3	-17.5	44.4	65	-20.6	58.8	72.4	-13.5	57.3	72.2	-14.9
SD	15.8	17.6	22.7	17	17.5	26.1	16.2	16.8	21.3	15.3	16.6	21.4
Sig.*			.0.003			0.002			0.01			0.006
GS	60.6	72.9	-12.6	51.3	61.8	-10.5	60.1	70.7	-10.6	59.4	70.2	-10.9
SD	14.8	17.6	16.3	13.8	19.8	24.0	13.9	18.4	15.4	13.2	17.6	15.6
Sig.*			0.003			NS			0.008			0.007
G+A	67.2	69.1	-1.9	57.8	64.1	-6.3	63	68.6	-5.6	63.4	68.3	-4.9
SD	13.3	16.9	14.0	15.7	17.6	17.7	8.7	13.1	11.0	8.1	12.9	101
Sig.*			NS			NS			NS			NS
p(ANCOVA)	0.039#		0.009	0.013#		NS	NS#		NS	NS#		NS

*Sig. = significance by within group paired t-test; 2-tailed; ANCOVA comparison between groups with baseline measure as covariate.
# = ANCOVA comparison between groups showing any differences at baseline for these parameters.

ISSN: 1475-2891