Table 2 WOMAC Index scores during the study period in 16 evaluable subjects
Study groups and time points | WOMAC Index scores, mean (SD) | |||
|---|---|---|---|---|
Pain | Stiffness | Physical function | Total symptoms | |
Hyal-Joint® (n = 8) | ||||
Baseline | 10.4 (3.6) | 4.2 (1.0) | 36.3 (7.7) | 50.9 (12.0) |
Week 4 | 8.8 (3.4) | 3.9 (1.6) | 28.1 (9.2) | 40.8 (13.6) |
Week 8 | 6.3 (4.0) | 2.9 (1.9) | 23.1 (15.1) | 32.3 (20.8) |
Change baseline vs week 4 | -1.6 (2.7) | -0.4 (1.5) | -8.1 (6.3) | -10.1 (9.6) |
P value | 0.135 | 0.504 | 0.008 | 0.020 |
Change baseline vs week 8 | -4.1 (3.4) | -1.4 (2.0) | -13.1 (12.0) | -18.6 (16.8) |
P value | 0.012 | 0.092 | 0.018 | 0.016 |
Placebo (n = 8) | ||||
Baseline | 10.4 (2.7) | 4.5 (1.9) | 37.4 (10.6) | 52.3 (13.6) |
Week 4 | 8.3 (3.0) | 3.5 (1.9) | 30.4 (10.7) | 42.1 (17.7) |
Week 8 | 6.4 (2.7) | 2.9 (1.0) | 27.3 (10.7) | 36.5 (13.7) |
Change baseline vs week 4 | -2.1 (3.3) | -1.0 (2.1) | -7.0 (10.8) | -10.1 (15.3) |
P value | 0.113 | 0.227 | 0.110 | 0.103 |
Change baseline vs week 8 | -4.0 (2.8) | -1.6 (0.9) | -10.1 (8.6) | -15.8 (11.4) |
P value | 0.005 | 0.002 | 0.012 | 0.006 |