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Table 2 WOMAC Index scores during the study period in 16 evaluable subjects

From: Effect of a natural extract of chicken combs with a high content of hyaluronic acid (Hyal-Joint®) on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trial

Study groups and time points WOMAC Index scores, mean (SD)
  Pain Stiffness Physical function Total symptoms
Hyal-Joint® (n = 8)     
   Baseline 10.4 (3.6) 4.2 (1.0) 36.3 (7.7) 50.9 (12.0)
   Week 4 8.8 (3.4) 3.9 (1.6) 28.1 (9.2) 40.8 (13.6)
   Week 8 6.3 (4.0) 2.9 (1.9) 23.1 (15.1) 32.3 (20.8)
   Change baseline vs week 4 -1.6 (2.7) -0.4 (1.5) -8.1 (6.3) -10.1 (9.6)
P value 0.135 0.504 0.008 0.020
   Change baseline vs week 8 -4.1 (3.4) -1.4 (2.0) -13.1 (12.0) -18.6 (16.8)
P value 0.012 0.092 0.018 0.016
Placebo (n = 8)     
   Baseline 10.4 (2.7) 4.5 (1.9) 37.4 (10.6) 52.3 (13.6)
   Week 4 8.3 (3.0) 3.5 (1.9) 30.4 (10.7) 42.1 (17.7)
   Week 8 6.4 (2.7) 2.9 (1.0) 27.3 (10.7) 36.5 (13.7)
   Change baseline vs week 4 -2.1 (3.3) -1.0 (2.1) -7.0 (10.8) -10.1 (15.3)
P value 0.113 0.227 0.110 0.103
   Change baseline vs week 8 -4.0 (2.8) -1.6 (0.9) -10.1 (8.6) -15.8 (11.4)
P value 0.005 0.002 0.012 0.006