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Table 2 List of possible causes and treatments for bipolar disorder including specific doses as well as supplementary information

From: Nutritional therapies for mental disorders

Mental Disorder Proposed Cause Treatment References
Bipolar Disorder Food allergies Avoid foods that elicit an allergic response [76, 77]
  Caffeine Avoid coffee and other caffeinated beverages [78]
  Inhibition of lithium from alkalizing agents Avoid alkalizing agents like bicarbonates [79]
  Vitamin B6 deficiency 100–200 milligrams/day [72, 80]
  Vitamin B12 deficiency 300–600 mcirograms/day [71, 81–83]
  Vitamin C deficiency 1–3 grams taken as divided doses [84–86]
  Folate deficiency 200 micrograms/day [9, 13, 71, 82, 83, 87, 88]
  Choline deficiency 10–30 grams of phosphatidyl form in divided doses [73, 89]
  Omega-3 or -6 deficiency 500–1000 milligrams/day [10, 11, 21, 39, 74, 75, 90–94]
  Phenylalanine deficiency Initially 500 milligrams/day; can increase to 3–4 grams/day [95, 96]
  Tryptophan deficiency 50–200 milligrams taken as divided doses [97–100]
  S-Adenosyl-L-Methionine (SAM) deficiency 800 milligrams [101–103]
  Melatonin deficiency 3–6 milligrams at 9 pm [104–106]
  Phosphatidylserine deficiency 100 milligrams with food [107]