Sparing effects of selenium and ascorbic acid on vitamin C and E in guinea pig tissues

Nutrition Journal

Table 3 Univariate significance tests for the effects of Se and AA intakes on vitamin C concentrations in guinea pig tissues¹

Tissue	Se Effect²			AA Effect ³			Se Effect (Trend)⁴
	AA	DHAA	Total	AA	DHAA	Total	AA	DHAA	Total
Liver	NSD	< 0.05	< 0.01	< 0.05	< 0.0001	< 0.0001	NSD	< 0.005	< 0.005
Heart	NSD	< 0.05	< 0.05	< 0.01	< 0.0001	< 0.0001	NSD	< 0.01	< 0.01
Kidney	< 0.05	NSD	NSD	< 0.005	< 0.0001	< 0.0001	< 0.05	NSD	NSD
Testis	NSD	NSD	< 0.05	< 0.0001	NSD	< 0.0001	< 0.05	NSD	< 0.005
Muscle	< 0.05	NSD	< 0.05	< 0.001	< 0.0001	< 0.0001	< 0.05	NSD	< 0.05
Spleen	NSD	< 0.05	< 0.01	< 0.0001	< 0.0001	< 0.0001	< 0.05	< 0.05	< 0.005
Plasma	NSD	NSD	NSD	< 0.0005⁵	NSD⁵	< 0.0001⁵	NSD	NSD	NSD

¹ Type III P values are shown; NSD = no statistical difference.
² Comparison between Se-D/MC, Se-M/MC and Se-N/MC guinea pigs killed at week 5 and 12, 48 and 24 hrs post AA dosing, respectively (n = 31).
³ Comparison between Se-N/MC and Se-N/NC guinea pigs killed at week 5 and 12, 48 and 24 hrs post AA dosing, respectively (n = 22).
⁴ Analyses to determine a decreasing or increasing trend with decreasing Se in the diet. Comparison of Se-D/MC, Se-M/MC and Se-N/MC guinea pigs killed at week 5 and 12, 48 and 24 hrs post AA dosing, respectively (n = 31). All significant values indicate a decreasing trend with decreasing Se in the diet, except for liver DHAA which indicates an increasing trend.
⁵ n = 20.

ISSN: 1475-2891