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Table 3 Associations of BMI, percent body fat, central fat (trunk fat), peripheral fat, and lean mass with serum leptin concentrations

From: Body Mass Index, percent body fat, and regional body fat distribution in relation to leptin concentrations in healthy, non-smoking postmenopausal women in a feeding study

  Leptin, ng/mL  
  Δ (95% C.I.) P-value Multiple R2
BMI    
Model 1 10.65 (8.16–13.19) < 0.0001 0.68
Model 2    
% Fat    
Model 1 7.77 (6.56–8.98) < 0.0001 0.82
Model 2 7.20 (4.72–9.75) < 0.0001 0.82
Central fat    
Model 1 11.93 (9.72–14.18) < 0.0001 0.77
Model 2 11.58 (5.87–17.61) 0.0002 0.77
Peripheral fat    
Model 1 10.55 (8.33–12.81) < 0.0001 0.72
Model 2 7.98 (2.13–14.16) 0.01 0.73
Lean mass    
Model 1 8.61 (3.76–13.68) 0.001 0.31
Model 2 -0.85 (-4.81–3.25) 0.68 0.68
  1. Δ - Percent change for serum leptin concentration for a one-unit change in each of the adiposity measures (i.e., percent change in leptin concentration per one-unit change in BMI, per 1% increase in total body fat, per 1 kg increase in central and peripheral fat and lean mass).
  2. Model 1: Adjusted for age, race, family history of breast cancer, parity and menarche < 12 years
  3. Model 2: Model 1 + BMI