Table 2 Genes and polymorphisms tested in the nutrigenetic patient group.
From: Improved weight management using genetic information to personalize a calorie controlled diet
Gene | Gene symbol | Polymorphism | % homozygote wild type | % heterozygote | % homozygote variant | HWE p < |
|---|---|---|---|---|---|---|
Angiotensin I converting enzyme | ACE | INS/DEL | 14.6% | 48.8% | 36.6% | 0.99 |
Apolipoprotein C-III | APOC3 | 3175C>G | 73.3% | 20.0% | 6.7% | 0.17 |
Cystathionine-beta-synthase | CBS | 699C>T | 53.5% | 41.9% | 4.7% | 0.81 |
Cholesteryl ester transfer protein | CETP | 279G>A | 48.8% | 39.5% | 11.6% | 0.86 |
Collagen, type I, alpha 1 | COL1A1 | G Sp1 T | 58.1% | 34.9% | 7.0% | 0.94 |
Glutathione S-transferase M1 | GSTM1 | Deletion (*) | 52.0% | 0.0% | 48.0% | N/A |
Glutathione S-transferase pi | GSTP1 | 313A>G | 57.8% | 33.3% | 8.9% | 0.68 |
341C>T | 56.8% | 34.1% | 9.1% | 1.00 | ||
Glutathione S-transferase theta 1 | GSTT1 | Deletion (*) | 86.0% | 0.0% | 14.0% | N/A |
Interleukin 6 | IL6 | -174G>C | 66.7% | 33.3% | 0.0% | 0.37 |
-634G>C | 86.0% | 14.0% | 0.0% | 0.89 | ||
Lipoprotein lipase | LPL | 1595C>G | 69.8% | 27.9% | 2.3% | 1.00 |
5-methyltetrahydrofolate-homocysteine methyltransferase reductase | MTRR | 66A>G | 19.0% | 45.2% | 35.7% | 0.90 |
5,10-methylenetetrahydrofolate reductase | MTHFR | 1298A>C | 34.0% | 48.9% | 17.0% | 1.00 |
677 C>T | 48.0% | 44.0% | 8.0% | 0.95 | ||
5-methyltetrahydrofolate-homocysteine methyltransferase | MTR | 2756A>G | 59.5% | 33.3% | 7.1% | 0.86 |
Nitric oxide synthase 3 (endothelial cell) | NOS3 | 894G>T | 44.2% | 44.2% | 11.6% | 1.00 |
Peroxisome proliferator-activated receptor gamma | PPARG | Pro12Ala | 75.6% | 15.6% | 8.9% | 0.02 |
Superoxide dismutase 2, mitochondrial | SOD2 | -28C>T | 10.0% | 54.0% | 36.0% | 0.57 |
Superoxide dismutase 3, extracellular | SOD3 | 760C>G | 100.0% | 0.0% | 0.0% | 1.00 |
Tumor necrosis factor | TNFα | -308G>A | 71.1% | 24.4% | 4.4% | 0.72 |
Vitamin D receptor | VDR | C Taq1 T | 23.3% | 46.5% | 30.2% | 0.91 |
T Bsm1 C | 23.3% | 46.5% | 30.2% | 0.91 | ||
T Fok1 C | 11.6% | 58.1% | 30.2% | 0.41 |