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Table 2 Genes and polymorphisms tested in the nutrigenetic patient group.

From: Improved weight management using genetic information to personalize a calorie controlled diet

Gene Gene symbol Polymorphism % homozygote wild type % heterozygote % homozygote variant HWE p <
Angiotensin I converting enzyme ACE INS/DEL 14.6% 48.8% 36.6% 0.99
Apolipoprotein C-III APOC3 3175C>G 73.3% 20.0% 6.7% 0.17
Cystathionine-beta-synthase CBS 699C>T 53.5% 41.9% 4.7% 0.81
Cholesteryl ester transfer protein CETP 279G>A 48.8% 39.5% 11.6% 0.86
Collagen, type I, alpha 1 COL1A1 G Sp1 T 58.1% 34.9% 7.0% 0.94
Glutathione S-transferase M1 GSTM1 Deletion (*) 52.0% 0.0% 48.0% N/A
Glutathione S-transferase pi GSTP1 313A>G 57.8% 33.3% 8.9% 0.68
   341C>T 56.8% 34.1% 9.1% 1.00
Glutathione S-transferase theta 1 GSTT1 Deletion (*) 86.0% 0.0% 14.0% N/A
Interleukin 6 IL6 -174G>C 66.7% 33.3% 0.0% 0.37
   -634G>C 86.0% 14.0% 0.0% 0.89
Lipoprotein lipase LPL 1595C>G 69.8% 27.9% 2.3% 1.00
5-methyltetrahydrofolate-homocysteine methyltransferase reductase MTRR 66A>G 19.0% 45.2% 35.7% 0.90
5,10-methylenetetrahydrofolate reductase MTHFR 1298A>C 34.0% 48.9% 17.0% 1.00
   677 C>T 48.0% 44.0% 8.0% 0.95
5-methyltetrahydrofolate-homocysteine methyltransferase MTR 2756A>G 59.5% 33.3% 7.1% 0.86
Nitric oxide synthase 3 (endothelial cell) NOS3 894G>T 44.2% 44.2% 11.6% 1.00
Peroxisome proliferator-activated receptor gamma PPARG Pro12Ala 75.6% 15.6% 8.9% 0.02
Superoxide dismutase 2, mitochondrial SOD2 -28C>T 10.0% 54.0% 36.0% 0.57
Superoxide dismutase 3, extracellular SOD3 760C>G 100.0% 0.0% 0.0% 1.00
Tumor necrosis factor TNFα -308G>A 71.1% 24.4% 4.4% 0.72
Vitamin D receptor VDR C Taq1 T 23.3% 46.5% 30.2% 0.91
   T Bsm1 C 23.3% 46.5% 30.2% 0.91
   T Fok1 C 11.6% 58.1% 30.2% 0.41
  1. Genotype frequencies in the study group and p-values for Hardy Weinberg Equilibrium (HWE) are shown. (*) the assay only measured presence or absence of the deletion so a HWE test is not applicable.