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Table 6 Nuclear receptor and COX-2 mRNA expression in colorectal tumors of patients with BMI ≥ 25

From: The effect of body weight on altered expression of nuclear receptors and cyclooxygenase-2 in human colorectal cancers

Gene

n

Healthy colon mucosa

Tumor tissue

pa

  

Median

Range

Median

Range

 

PPARγ

11

0.95

(0.35–2.11)

0.97

(0.28–4.71)

n.s.

PPARδ

11

1.28

(0.72–2.00)

1.52

(0.40–4.49)

0.022

RXRα

11

0.64

(0.20–1.25)

0.85

(0.21–3.49)

0.047

RARα

11

1.17

(0.72–1.88)

1.44

(0.38–3.72)

0.018

RARβ

11

1.30

(0.12–5.39)

2.12

(0.24–10.82)

0.014

RARγ

11

1.60

(0.49–9.52)

3.17

(0.83–15.80)

<0.001

COX-2

11

2.93

(0.44–6.75)

13.20

(0.85–166.86)

<0.001