The effect of body weight on altered expression of nuclear receptors and cyclooxygenase-2 in human colorectal cancers

Table 5 Nuclear receptor and COX-2 mRNA expression in colorectal tumors of patients with BMI < 25

Gene	n	Healthy colon mucosa		Tumor tissue		p^a
		Median	Range	Median	Range
PPARγ	9	1.00	(0.65–3.19)	1.17	(0.35–3.67)	n.s.
PPARδ	9	1.35	(0.69–2.34)	1.55	(0.57–4.96)	0.012
RXRα	9	0.76	(0.37–1.20)	1.09	(0.54–1.84)	<0.001
RARα	9	1.09	(0.69–1.85)	1.58	(0.95–3.93)	<0.001
RARβ	9	1.53	(0.52–2.49)	2.78	(0.18–8.49)	0.001
RARγ	9	1.21	(0.76–3.68)	4.49	(0.91–9.68)	<0.001
COX-2	9	1.11	(0.51–3.48)	12.40	(0.50–560.46)	<0.001

ISSN: 1475-2891