Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behavior in children with attention deficit hyperactivity disorder

Table 2 Fatty acids from the isolated plasma phospholipids described as means ± SD and median.*

Plasma FA		Baseline	Week 4	Week 8
	n-6
18:2 (LA)		22.61 ± 1.39	17.81 ± 2.85	21.88 ± 4.89
median		21.95	17.49	21.08
20:3 (DGLA)		3.12 ± 0.44	1.86 ± 0.82	2.15 ± 0.64
median		3.09	2.25	2.05
20:4 (AA)		9.52 ± 0.70	8.92 ± 0.83	8.69 ± 1.30
median		9.34	8.92	8.37
	n-3
18:3 (LNA)		0.13 ± 0.07	0.13 ± 0.07	0.13 ± 0.06
median		0.13	0.1	0.12
20:5 (EPA)		0.49 ± 0.12	5.89 ± 4.27^a	4.64 ± 3.65^a
median		0.46	6.13	4.72
22:6 (DHA)		2.30 ± 0.88	5.68 ± 1.28^a	5.61 ± 2.14^a
median		2.07	6.11	6.19
Totals and ratios
Saturated		44.29 ± 0.99	43.94 ± 1.26	42.19 ± 1.05
median		44.2	44.04	42.53
Monounsaturated		15.43 ± 1.38	13.64 ± 1.18	12.31 ± 2.12
median		15.7	13.51	11.93
Polyunsaturated		40.27 ± 1.03	42.41 ± 1.43	45.51 ± 1.26
median		40.21	42.02	45.38
total n-6		36.37 ± 0.99	29.07 ± 4.31^a	33.42 ± 5.67
median		36.57	29.54	31.59
total n-3		3.90 ± 0.87	13.35 ± 5.27^a	12.09 ± 6.17^a
median		3.66	12.74	13.38
n-6: n-3 ratio		9.74 ± 2.14	2.79 ± 1.88^a	3.93 ± 2.73^a
median		9.61	2.39	2.36
AA:EPA ratio		20.78 ± 5.26	4.19 ± 5.45^a	5.95 ± 7.35^a
median		20.14	1.46	1.69
AA:EPA ratio (n = 7)^#		20.73 ± 5.26	2.53 ± 3.49^a	2.52 ± 2.91
median		19.58	1.34	1.39

* Values are mean ± SD and medians (n = 9). ^a p < 0.01 using Wilcoxon signed rank test to compare to baseline. LA, linoleic acid; DGLA, dihomogammalinolenic acid; AA, arachidonic acid; LNA, linolenic acid; EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid.

ISSN: 1475-2891